… or by chemical modifications of the DNA itself. DNA methylation was the first epigenetic
modification to be described. In higher eukaryotes, DNA is methylated mainly on the position 5 …

… for dogs and wolves (10) described one of the first nonhuman epigenetic clocks. We determined
that the age dependence of DNA methylation (… based on 93 recognized dog breeds (11) …

… old dogs). A statistically significant difference was found in the global DNA methylation level
between pups and adolescent dogs and between adult and old dogs (over 8 years) (Tab. 1). …

… To test for more distant evolutionary conservation of age effects on DNA methylation
between canids and humans, we computed age correlations over a set of 729 human blood …

… DNA methylation and mammalian life stage remain unanswered (Figure 1). While the rate of
methylation … were obtained when pairing young dogs with old humans or vice versa (Figure …

… in seven of the 11 dogs. The maximum difference … -old dog whose predicted age based on
methylation of two CpG sites was 70.8 months. Marked diremption was observed in some dogs…

… of DNA methylation levels of KISS1R and BCS of these dogs … of DNA methylation levels of
CAPS2 and BCS of these dogs (… the samples of dogs with age of 84 months (7 years old) and …

… DNA methylation differences between wolf and dog and between the dog breeds. The … Zoo
in connection with routine euthanasia of two 2 years old and one 9 year old surplus animals. …

… , old age, … -dog) clocks, we added 1,207 human DNA methylation profiles derived from the
same custom array, which measures methylation levels at 37,492 cytosines with flanking DNA …

… These “epigenetic clocks,” most of which have been built using DNA methylation (DNAm) …
of domesticated dogs. We measured DNAm and ATAC‐seq profiles for 71 dogs, building …