DNA methylation as a therapeutic target in hematologic disorders: recent results in older patients with myelodysplasia and acute myeloid leukemia
B Rüter, PW Wijermans, M Lübbert - International journal of hematology, 2004 - Springer
… inhibit DNA methylation have been developed to specifically target this hypermethylation …
more than 25 years ago, when their methylation-inhibitory activities, even at low concentrations…
more than 25 years ago, when their methylation-inhibitory activities, even at low concentrations…
Global DNA methylation in old subjects is correlated with frailty
… global DNA methylation levels and frailty. We found that the global DNA methylation levels
… to a significant decrease in the global DNA methylation levels. These results suggest that …
… to a significant decrease in the global DNA methylation levels. These results suggest that …
DNA methylation pattern of gene promoters of major neurotransmitter systems in older patients with schizophrenia with severe and mild cognitive impairment
R Alelú‐Paz, A González‐Corpas… - … journal of geriatric …, 2015 - Wiley Online Library
… DNA methylation patterns in multiple gene promoters in several brain structures from older
patients … an analysis in the normal and schizophrenic older human brain. Our results indicate …
patients … an analysis in the normal and schizophrenic older human brain. Our results indicate …
Age-associated decrease in global DNA methylation in patients with major depression
… In summary, although we found a decrease in global DNA methylation in older patients with
depression compared to healthy controls, this can possibly be explained by the fact that the …
depression compared to healthy controls, this can possibly be explained by the fact that the …
The role of DNA methylation in aging, rejuvenation, and age-related disease
AA Johnson, K Akman, SRG Calimport… - Rejuvenation …, 2012 - liebertpub.com
… Aging is strongly correlated with changes in DNA methylation. DNA methylation and …
Global DNA methylation in old subjects is correlated with frailty. Age (Dordr) 2012;34:169–…
Global DNA methylation in old subjects is correlated with frailty. Age (Dordr) 2012;34:169–…
Age-related DNA methylation changes in normal human prostate tissues
… age-related manner, suggesting that the use of GSTP1 as a diagnostic tool must be carried
out with caution especially when using it as a tool for analyzing samples from older patients. …
out with caution especially when using it as a tool for analyzing samples from older patients. …
Role of age-related changes in DNA methylation in the disproportionate susceptibility and worse outcomes of sepsis in older adults
X Lang, L Shen, T Zhu, W Zhao, Y Chen, C Zhu… - Frontiers in …, 2022 - frontiersin.org
… Our results demonstrated the existence of DNA methylation changes in sepsis patients vs.
controls, supporting that epigenetic alterations may play an important role in the pathogenesis …
controls, supporting that epigenetic alterations may play an important role in the pathogenesis …
Association between early promoter-specific DNA methylation changes and outcome in older acute myeloid leukemia patients
NJ Achille, M Othus, K Phelan, S Zhang, K Cooper… - Leukemia research, 2016 - Elsevier
… Here we report DNA methylation and gene expression analyses in peripheral blood samples
from a phase 2 trial of older patients with AML treated with azacitine and GO therapy. We …
from a phase 2 trial of older patients with AML treated with azacitine and GO therapy. We …
[HTML][HTML] Accelerated DNA methylation age and the use of antihypertensive medication among older adults
… patients with hypertension [18,19], and may also be associated with a decreased risk of
cognitive decline and incident dementia [20]. As DNA methylation … cohort of older veterans living …
cognitive decline and incident dementia [20]. As DNA methylation … cohort of older veterans living …
Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies
… has never been done before in examining association of DNA methylation with age. Our
results suggest that the association of DNA methylation with age is inflated when common …
results suggest that the association of DNA methylation with age is inflated when common …
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