Epigenetic drivers in pediatric medulloblastoma
MF Roussel, JL Stripay - The Cerebellum, 2018 - Springer
… DNA Methylation Genome-wide DNA methylation arrays currently examine 850,000 CpG …
These analyses suggest that DNA methylation plays a major role in the pathogenesis of MB …
These analyses suggest that DNA methylation plays a major role in the pathogenesis of MB …
DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas
A Korshunov, F Sahm, O Zheludkova… - Neuro …, 2019 - academic.oup.com
… We found that DNA methylation profiling discloses significant advantages for molecular
diagnostic of WNT MB. All other “routine” methods applied, such as ß-catenin …
diagnostic of WNT MB. All other “routine” methods applied, such as ß-catenin …
… reference-independent methylation status (aPRIMES) identifies frequent promoter methylation and consecutive downregulation of ZIC2 in pediatric medulloblastoma
S Pfister, C Schlaeger, F Mendrzyk… - Nucleic acids …, 2007 - academic.oup.com
… in medulloblastoma by aberrant methylation of its promoter … for ZIC2 in the pathogenesis of
pediatric medulloblastoma. … tool to identify genes regulated by DNA methylation, such as in …
pediatric medulloblastoma. … tool to identify genes regulated by DNA methylation, such as in …
Gene-Specific DNA Methylation Profiles in Pediatric Medulloblastomas
… We think that customized DNA methylation profiling may be a useful tool in the molecular
subclassification of pediatric medulloblastoma and a potential technical approach in precision …
subclassification of pediatric medulloblastoma and a potential technical approach in precision …
DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences
SJ Diede, J Guenthoer, LN Geng… - Proceedings of the …, 2010 - National Acad Sciences
… , we describe a genomewide DNA methylation assay that identifies CpG methylation on the
… (T m ) of DNA. We show that this denaturation analysis of methylation differences method …
… (T m ) of DNA. We show that this denaturation analysis of methylation differences method …
Aberrant promoter methylation of previously unidentified target genes is a common abnormality in medulloblastomas–implications for tumor biology and potential …
MC Frühwald, MS O'Dorisio, Z Dai, SM Tanner… - Oncogene, 2001 - nature.com
… Methylation patterns differed between medulloblastomas and PNETs. Examination of several
methylated … We suggest that DNA hypermethylation has an outstanding potential for the …
methylated … We suggest that DNA hypermethylation has an outstanding potential for the …
Advances in the classification of pediatric brain tumors through DNA methylation profiling: from research tool to frontline diagnostic
… In particular, DNA methylation profiling has emerged as a … malignant pediatric brain
tumors, namely medulloblastoma, … the potential role of DNA methylation profiling as a frontline …
tumors, namely medulloblastoma, … the potential role of DNA methylation profiling as a frontline …
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma
… In this study, we identified 6598 differentially methylated CpGs in … Furthermore, DNA
methylation changes in serial CSF … , we identified reliable MB DNA methylation signatures in …
methylation changes in serial CSF … , we identified reliable MB DNA methylation signatures in …
Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines
K Harada, S Toyooka, A Maitra, R Maruyama… - Oncogene, 2002 - nature.com
… we studied its expression in methylation positive and negative pediatric tumor cell lines.
We … and one medulloblastoma), and these cell lines had a methylated RASSF1A allele but …
We … and one medulloblastoma), and these cell lines had a methylated RASSF1A allele but …
MethPed: a DNA methylation classifier tool for the identification of pediatric brain tumor subtypes
A Danielsson, S Nemes, M Tisell, B Lannering… - Clinical …, 2015 - Springer
… Among the four medulloblastomas, three could be further subgrouped … medulloblastoma
tumor groups, but one case did not share the methylation profile of any of the medulloblastoma …
tumor groups, but one case did not share the methylation profile of any of the medulloblastoma …
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