Periostin in the Kidney

DP Wallace - Periostin, 2019 - Springer
… In PKD mice, periostin overexpression accelerates cyst growth and contributes to structural
… Although we recognize that periostin contributes to kidney disease, several questions …

[HTML][HTML] Periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney disease

DP Wallace, C White, L Savinkova, E Nivens, GA Reif… - Kidney international, 2014 - Elsevier
… In this study, we show that periostin is also highly overexpressed in human ARPKD and …
Currently, the role of periostin in other chronic kidney diseases remains unclear. Periostin

Periostin in kidney diseases

N Prakoura, C Chatziantoniou - Cellular and Molecular Life Sciences, 2017 - Springer
Periostin overexpression in cultured mouse distal tubular cells downregulated the expression
of E-cadherin and induced expression of mesenchymal markers like fibroblast specific …

Inhibition of periostin expression protects against the development of renal inflammation and fibrosis

M Mael-Ainin, A Abed, SJ Conway… - Journal of the …, 2014 - journals.lww.com
… Our results show that periostin is highly induced locally during renal disease and that its …
To our knowledge, this study is the first attempt to block overexpression of periostin in vivo by …

Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease

A Raman, SC Parnell, Y Zhang… - … Physiology-Renal …, 2018 - journals.physiology.org
kidney disease (PKD) kidneys. In this study, we determined that selective overexpression of
periostin in … However, we found that the overexpression of periostin in pcy kidneys stimulated …

The role of periostin in kidney diseases

A Turczyn, M Pańczyk-Tomaszewska - Central European Journal of …, 2021 - termedia.pl
… It was observed that 24 and 72 hours after I/R, mice overexpressing periostin had preserved
kidney function, less severe necrosis and dilation of the tubules, and lower expression of …

Periostin contributes to renal and cardiac dysfunction in rats with chronic kidney disease: Reduction of PPARα

X Bian, X Su, Y Wang, G Zhao, B Zhang, D Li - Biochimie, 2019 - Elsevier
kidney failure, which involves removal of one kidney and 2/3 of the other. Chronic renal failure
… Since the expression of PPARα is reduced when POSTN is overexpressed, we assumed …

Knockdown of periostin attenuates 5/6 nephrectomy‐induced intrarenal renin–angiotensin system activation, fibrosis, and inflammation in rats

X Bian, Y Bai, X Su, G Zhao, G Sun… - Journal of cellular …, 2019 - Wiley Online Library
renal function following unilateral ureteral obstruction (UUO; Hwang et al., 2017). This study
reveals the pathologic role of periostin in renal disease … from periostin overexpressed HK-2 …

[HTML][HTML] Periostin and polycystic kidney disease: more pieces in the puzzle

EH Watanabe, AG Amaral… - … of Physiology-Renal …, 2019 - journals.physiology.org
… 5) shows that periostin overexpression in CD does not result in renal cyst or fibrosis … renal
function decline and decreased survival. Importantly, periostin overexpression increased renal

Periostin: novel tissue and urinary biomarker of progressive renal injury induces a coordinated mesenchymal phenotype in tubular cells

B Satirapoj, Y Wang, MP Chamberlin… - Nephrology Dialysis …, 2012 - academic.oup.com
renal expression and urine excretion of periostin in experimental models of renal disease
and in the urine of CKD patients… also demonstrates that periostin overexpression in cultured …