… NH 2 and COOH termini to identify polycystin-2 as an ∼110-kDa integral membrane
glycoprotein. Polycystin-2 … typical of pre-middle Golgi proteins. Immunofluorescent cell staining of …

… Targeted mutations in the murine pkd1 and pkd2 genes also produce a cystic phenotype,
suggesting that the protein products of these two genes, polycystin-1 and polycystin-2, may …

… The protein products of pkd1 and pkd2, originally called … or polycystin-1 and 2, respectively,
are large, membrane-associated proteins with putative roles in signal transduction and Ca 2…

… Polycystin-2, the protein product of PKD2, is also predicted to encode an integral membrane
protein … Polycystin-2 has significant amino acid homology to the trp family of store-operated (…

… The recent observations that polycystin-1, the product of PKD1, … polycystin-2 are also
expressed in cultured aortic smooth muscle cells and that the pattern of expression of polycystin-2 …

… sequence predicted on the basis of nucleotide sequence of RT-PCR products amplified
from MO-injected embryos. In-frame deletions are shown in gray for MOex3, MOex5, and …

… , TRPML) and polycystin-2 proteins (transient receptor potential polycystin, TRPP) constitute
… to a C-terminal subregion of polycystin-1, the gene product of PKD1. A number of additional …

… /polyductin (FPC), polycystin-1 (PC1), and polycystin-2 (PC2) are all … of FPC, the protein
product encoded by the PKHD1 gene … These findings suggest that FPC and polycystins share, at …

… formation, two transgenic rat lines that contain a truncated human polycystin-2 cDNA were
generated. The protein product lacks almost the entire COOH-terminus and mimics mutations …

… Polycystin-2, the product of the gene mutated in type 2 autosomal dominant polycystic
kidney disease (ADPKD), is the prototypical member of a subfamily of the transient receptor …