Age-associated DNA methylation in pediatric populations

RS Alisch, BG Barwick, P Chopra, LK Myrick… - Genome …, 2012 - genome.cshlp.org
… Here we investigate the normal variation of DNA methylation in the peripheral blood of a
large pediatric cohort using a highly sensitive genome-wide assay that quantitates methylation

Childhood adversity and DNA methylation in two population-based cohorts

LC Houtepen, R Hardy, J Maddock, D Kuh… - Translational …, 2018 - nature.com
… in NSHD with buccal DNA and ACE data, who also had blood DNA methylation measured
at the same time point, the tissue specificity of childhood adversity related changes in DNA

Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context

BC Christensen, EA Houseman, CJ Marsit… - PLoS …, 2009 - journals.plos.org
… Thus, population-based investigations are needed to further … -specific differences in DNA
methylation and to discern how … determinant of normal tissue-specificity. This work highlights …

Trends in DNA methylation with age replicate across diverse human populations

S Gopalan, O Carja, M Fagny, E Patin, JW Myrick… - Genetics, 2017 - academic.oup.com
… the impact of genetic ancestry and cell specificity on epigenetic aging, we measured DNA
of cosmopolitan populations. By using DNA methylation data from these populations, we are …

Population DNA methylation studies in the Developmental Origins of Health and Disease (DOHaD) framework

JF Felix, CAM Cecil - Journal of developmental origins of health and …, 2019 - cambridge.org
… in population research. We discuss the application of DNA methylation in early-life population
… The tissue specificity of DNA methylation is an additional challenge to causal inference …

Discordance of DNA methylation variance between two accessible human tissues

R Jiang, MJ Jones, E Chen, SM Neumann, HB Fraser… - Scientific reports, 2015 - nature.com
DNA methylation differences between matched peripheral blood mononuclear cells (PMBCs)
and buccal epithelial cells (BECs), the two most accessible tissues for populationspecificity

Principles and challenges of genome-wide DNA methylation analysis

PW Laird - Nature Reviews Genetics, 2010 - nature.com
… of DNA methylation analysis, with a particular emphasis on genome-scale DNA methylation
… The low-specificity of the recognition site for McrBC (R me C...R me C, in which R is A or G) …

Tissue-specific differences in DNA methylation in various mammals

MA Gama-Sosa, RM Midgett, VA Slagel… - … et Biophysica Acta (BBA …, 1983 - Elsevier
… in overall levels of human DNA methylation and the extent of … of DNA methylation in
eucaryotes, we have analyzed the 5-methylcytosine content of DNA for different cell populations of …

DNA methylation-based predictors of health: applications and statistical considerations

PD Yousefi, M Suderman, R Langdon… - Nature Reviews …, 2022 - nature.com
… genetic risk estimates, DNA methylation varies dynamically in … to the development of DNA
methylation-based predictors … the progress of existing DNA methylation-based predictors, …

Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma

JA Tsou, JS Galler, KD Siegmund, PW Laird, S Turla… - Molecular cancer, 2007 - Springer
… a sensitivity of 67–86% and specificity of 74–82%. DNA methylation of these loci did not differ
… While the population analyzed in the current study is small, we reasoned that an indication …