Age-associated DNA methylation in pediatric populations
RS Alisch, BG Barwick, P Chopra, LK Myrick… - Genome …, 2012 - genome.cshlp.org
… Here we investigate the normal variation of DNA methylation in the peripheral blood of a
large pediatric cohort using a highly sensitive genome-wide assay that quantitates methylation …
large pediatric cohort using a highly sensitive genome-wide assay that quantitates methylation …
Childhood adversity and DNA methylation in two population-based cohorts
… in NSHD with buccal DNA and ACE data, who also had blood DNA methylation measured
at the same time point, the tissue specificity of childhood adversity related changes in DNA …
at the same time point, the tissue specificity of childhood adversity related changes in DNA …
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
… Thus, population-based investigations are needed to further … -specific differences in DNA
methylation and to discern how … determinant of normal tissue-specificity. This work highlights …
methylation and to discern how … determinant of normal tissue-specificity. This work highlights …
Trends in DNA methylation with age replicate across diverse human populations
… the impact of genetic ancestry and cell specificity on epigenetic aging, we measured DNA …
of cosmopolitan populations. By using DNA methylation data from these populations, we are …
of cosmopolitan populations. By using DNA methylation data from these populations, we are …
Population DNA methylation studies in the Developmental Origins of Health and Disease (DOHaD) framework
JF Felix, CAM Cecil - Journal of developmental origins of health and …, 2019 - cambridge.org
… in population research. We discuss the application of DNA methylation in early-life population
… The tissue specificity of DNA methylation is an additional challenge to causal inference …
… The tissue specificity of DNA methylation is an additional challenge to causal inference …
Discordance of DNA methylation variance between two accessible human tissues
… DNA methylation differences between matched peripheral blood mononuclear cells (PMBCs)
and buccal epithelial cells (BECs), the two most accessible tissues for population … specificity…
and buccal epithelial cells (BECs), the two most accessible tissues for population … specificity…
Principles and challenges of genome-wide DNA methylation analysis
PW Laird - Nature Reviews Genetics, 2010 - nature.com
… of DNA methylation analysis, with a particular emphasis on genome-scale DNA methylation
… The low-specificity of the recognition site for McrBC (R me C...R me C, in which R is A or G) …
… The low-specificity of the recognition site for McrBC (R me C...R me C, in which R is A or G) …
Tissue-specific differences in DNA methylation in various mammals
MA Gama-Sosa, RM Midgett, VA Slagel… - … et Biophysica Acta (BBA …, 1983 - Elsevier
… in overall levels of human DNA methylation and the extent of … of DNA methylation in
eucaryotes, we have analyzed the 5-methylcytosine content of DNA for different cell populations of …
eucaryotes, we have analyzed the 5-methylcytosine content of DNA for different cell populations of …
DNA methylation-based predictors of health: applications and statistical considerations
… genetic risk estimates, DNA methylation varies dynamically in … to the development of DNA
methylation-based predictors … the progress of existing DNA methylation-based predictors, …
methylation-based predictors … the progress of existing DNA methylation-based predictors, …
Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma
JA Tsou, JS Galler, KD Siegmund, PW Laird, S Turla… - Molecular cancer, 2007 - Springer
… a sensitivity of 67–86% and specificity of 74–82%. DNA methylation of these loci did not differ
… While the population analyzed in the current study is small, we reasoned that an indication …
… While the population analyzed in the current study is small, we reasoned that an indication …