Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
… promoter methylation (Fig. 1d). In agreement with the link between promoter DNA methylation
… 3 , we also observed that promoter DNA methylation was higher on the X chromosome …
… 3 , we also observed that promoter DNA methylation was higher on the X chromosome …
Targets and dynamics of promoter DNA methylation during early mouse development
J Borgel, S Guibert, Y Li, H Chiba, D Schübeler… - Nature …, 2010 - nature.com
… We conclude that promoter DNA methylation acquired in epiblast can be … at promoters with
moderate CpG richness during somatic development. Figure 3: Promoter DNA methylation at …
moderate CpG richness during somatic development. Figure 3: Promoter DNA methylation at …
Epigenetic biomarkers of promoter DNA methylation in the new era of cancer treatment
K Yamashita, K Hosoda, N Nishizawa, H Katoh… - Cancer …, 2018 - Wiley Online Library
… review the published literatures describing DNA methylation in the promoters of critical
tumor suppressor genes; detection of promoter DNA methylation in various body fluids permits …
tumor suppressor genes; detection of promoter DNA methylation in various body fluids permits …
Transient cyclical methylation of promoter DNA
S Kangaspeska, B Stride, R Métivier… - Nature, 2008 - nature.com
… actively transcribed, DNA methylation occurs after the … methylation cycling of the pS2
promoter in cell lines in which pS2 expression is quiescent and the proximal promoter is methylated…
promoter in cell lines in which pS2 expression is quiescent and the proximal promoter is methylated…
Cyclical DNA methylation of a transcriptionally active promoter
R Métivier, R Gallais, C Tiffoche, C Le Péron… - Nature, 2008 - nature.com
… of the pS2 promoter 14 . Significantly, the NuRD complex engages the promoter 2 h after E 2
… We envisioned that DNA methylation may target NuRD to the promoter at this specific time, …
… We envisioned that DNA methylation may target NuRD to the promoter at this specific time, …
DNA methylation and gene expression
Z Siegfried, I Simon - Wiley Interdisciplinary Reviews: Systems …, 2010 - Wiley Online Library
… The third and smallest group (7%) represents CGI promoters that are DNA methylated (filled
circles). There is no clear correlation between this group and any specific chromatin marks (…
circles). There is no clear correlation between this group and any specific chromatin marks (…
DNA methylation landscapes: provocative insights from epigenomics
MM Suzuki, A Bird - Nature reviews genetics, 2008 - nature.com
… that sees DNA methylation primarily … DNA methylation — are currently seen as limited.
However, studies of large numbers of promoters have revealed many at which DNA methylation …
However, studies of large numbers of promoters have revealed many at which DNA methylation …
DNA methylation and cancer
M Kulis, M Esteller - Advances in genetics, 2010 - Elsevier
… The majority of the promoters affected by loss of DNA methylation belong to tissue-specific
genes. For instance, a family of cancer/testis (CT) antigens, which are restricted to adult …
genes. For instance, a family of cancer/testis (CT) antigens, which are restricted to adult …
Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging
MT Bocker, I Hellwig, A Breiling… - Blood, The Journal …, 2011 - ashpublications.org
… SLAMF7 was restricted to the promoter region, whereas the gene body remained methylated,
which is consistent with a specific role of promoter DNA methylation in gene silencing. Our …
which is consistent with a specific role of promoter DNA methylation in gene silencing. Our …
Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets
BT Yang, TA Dayeh, CL Kirkpatrick, J Taneera… - Diabetologia, 2011 - Springer
… for 72 h increased insulin promoter DNA methylation in clonal rat beta cells. Although we
cannot rule out that the changes we find in insulin promoter DNA methylation in type 2 diabetic …
cannot rule out that the changes we find in insulin promoter DNA methylation in type 2 diabetic …