Insulin gene expression is regulated by DNA methylation
… In general, DNA methylation has a suppressive effect on … human and mouse insulin promoters,
where complete methylation … , methylation of the individual sites in the mouse promoter …
where complete methylation … , methylation of the individual sites in the mouse promoter …
The role of DNA methylation in cancer development.
MW Luczak, PP Jagodziński - Folia histochemica et …, 2006 - journals.viamedica.pl
… aberrations in genomic DNA methylation that include hypermethylation and hypomethylation
of promoter or first exon of cancer-related genes. Hypermethylation of promoter of various …
of promoter or first exon of cancer-related genes. Hypermethylation of promoter of various …
Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation
GH Rauscher, JK Kresovich, M Poulin, L Yan, V Macias… - BMC cancer, 2015 - Springer
… tissue can contain early changes in DNA methylation that may … the prevalence of early DNA
methylation changes and field … ) in breast cancer development using paired adjacent normal …
methylation changes and field … ) in breast cancer development using paired adjacent normal …
Dynamics and context-dependent roles of DNA methylation
C Ambrosi, M Manzo, T Baubec - Journal of molecular biology, 2017 - Elsevier
… DNA methylation dynamics during early mouse development … red) and paternal (blue)
methylation. This indicates the major … The requirement of de novo DNA methylation at promoters of …
methylation. This indicates the major … The requirement of de novo DNA methylation at promoters of …
Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis
… mouse early organogenesis [42], together with promoters, CpG islands and intergenic repeat
elements. As expected, we find that regulatory regions associated with the blood trajectory …
elements. As expected, we find that regulatory regions associated with the blood trajectory …
Expression of the peroxisome proliferator activated receptor γ gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes
K Fujiki, F Kano, K Shiota, M Murata - BMC biology, 2009 - Springer
… by DNA methylation of its promoter region … first investigated and compared the DNA
methylation of the PPARγ gene in SAT and VAT. In the case of SAT, the age (in weeks) of the mice …
methylation of the PPARγ gene in SAT and VAT. In the case of SAT, the age (in weeks) of the mice …
Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome
… Interestingly, methylation at these sites exhibits a strong dependence on … DNA methylation
machinery. Finally, we report a surprising presence of non-CG methylation in the adult mouse …
machinery. Finally, we report a surprising presence of non-CG methylation in the adult mouse …
Epigenetic DNA methylation in the promoters of the Igf1 receptor and insulin receptor genes in db/db mice
A Nikoshkov, VG Sunkari, O Savu, E Forsberg… - Epigenetics, 2011 - Taylor & Francis
… Sequencing revealed an almost total absence of methylation events in all (male and female…
regulation by DNA methylation in this region of the Igf1 promoter in mouse muscle tissue. …
regulation by DNA methylation in this region of the Igf1 promoter in mouse muscle tissue. …
DNA methylation represses transcription in vivo
Z Siegfried, S Eden, M Mendelsohn, X Feng… - Nature …, 1999 - nature.com
… To test whether DNA methylation inhibits gene transcription in vivo , we used the IE to
artificially undermethylate a tissue-specific promoter region and examined expression of a reporter…
artificially undermethylate a tissue-specific promoter region and examined expression of a reporter…
Dnmt1 binds and represses genomic retroelements via DNA methylation in mouse early embryos
B Min, JS Park, YS Jeong, K Jeon… - Nucleic Acids …, 2020 - academic.oup.com
… through DNA methylation in early mouse development. … We listed the genes with DnmtDam
peaks at promoters and … levels among the groups using early embryo RNA-seq datasets, …
peaks at promoters and … levels among the groups using early embryo RNA-seq datasets, …