DNA methylation is an important component of epigenetic modifications that influences the
transcriptional machinery and is aberrant in many human diseases. Several methods have …

DNA methylation plays a key role in regulating eukaryotic gene expression. Although
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …

Background Mislabeled, contaminated or poorly performing samples can threaten power in
methylation microarray analyses or even result in spurious associations. We describe a set …

Background Genome-wide methylation profiling has led to more comprehensive insights
into gene regulation mechanisms and potential therapeutic targets. Illumina Human …

We have developed a high-throughput method for analyzing the methylation status of
hundreds of preselected genes simultaneously and have applied it to the discovery of …

Motivation High-dimensional DNA methylation (DNAm) array coverage, while sparse in the
context of the entire DNA methylome, still constitutes a very large number of CpG probes …

With the rapid development of genome-wide high-throughput technologies, including
expression arrays, SNP arrays and next-generation sequencing platforms, enormous …

Epigenome-wide association studies (EWASs) have become increasingly popular for
studying DNA methylation (DNAm) variations in complex diseases. The Illumina methylation …

There are numerous approaches to decipher a whole genome DNA methylation profile
(“methylome”), each varying in cost, throughput and resolution. The gold standard of these …

DNA methylation is a widely investigated epigenetic mark with important roles in
development and disease. High-throughput assays enable genome-scale DNA methylation …