Methyl-DNA immunoprecipitation (MeDIP): hunting down the DNA methylome
FV Jacinto, E Ballestar, M Esteller - Biotechniques, 2008 - Taylor & Francis
One of the most challenging projects in the field of epigenetics is the generation of detailed
functional maps of DNA methylation in different cell and tissue types in normal and disease …
functional maps of DNA methylation in different cell and tissue types in normal and disease …
Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …
DNA methylation differences associated with complex phenotypes. Many of the challenges …
DNA unmethylome profiling by covalent capture of CpG sites
Dynamic patterns of cytosine-5 methylation and successive hydroxylation are part of
epigenetic regulation in eukaryotes, including humans, which contributes to normal …
epigenetic regulation in eukaryotes, including humans, which contributes to normal …
Using high-density DNA methylation arrays to profile copy number alterations
The integration of genomic and epigenomic data is an increasingly popular approach for
studying the complex mechanisms driving cancer development. We have developed a …
studying the complex mechanisms driving cancer development. We have developed a …
Whole-genome DNA methylation profiling using MethylCap-seq
AB Brinkman, F Simmer, K Ma, A Kaan, J Zhu… - Methods, 2010 - Elsevier
MethylCap-seq is a robust procedure for genome-wide profiling of DNA methylation. The
approach consists of the capture of methylated DNA using the MBD domain of MeCP2, and …
approach consists of the capture of methylated DNA using the MBD domain of MeCP2, and …
Profiling DNA methylation based on next-generation sequencing approaches: new insights and clinical applications
D Barros-Silva, CJ Marques, R Henrique, C Jerónimo - Genes, 2018 - mdpi.com
DNA methylation is an epigenetic modification that plays a pivotal role in regulating gene
expression and, consequently, influences a wide variety of biological processes and …
expression and, consequently, influences a wide variety of biological processes and …
Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
Genomic DNA methylation profiles exhibit substantial variation within the human population,
with important functional implications for gene regulation. So far little is known about the …
with important functional implications for gene regulation. So far little is known about the …
“Gap hunting” to characterize clustered probe signals in Illumina methylation array data
Abstract Background The Illumina 450k array has been widely used in epigenetic
association studies. Current quality-control (QC) pipelines typically remove certain sets of …
association studies. Current quality-control (QC) pipelines typically remove certain sets of …
DMRfinder: efficiently identifying differentially methylated regions from MethylC-seq data
JM Gaspar, RP Hart - BMC bioinformatics, 2017 - Springer
Background DNA methylation is an epigenetic modification that is studied at a single-base
resolution with bisulfite treatment followed by high-throughput sequencing. After alignment …
resolution with bisulfite treatment followed by high-throughput sequencing. After alignment …
Genome-wide DNA methylation profiling using the methylation-dependent restriction enzyme LpnPI
R Boers, J Boers, B de Hoon, C Kockx, Z Ozgur… - Genome …, 2018 - genome.cshlp.org
DNA methylation is a well-known epigenetic modification that plays a crucial role in gene
regulation, but genome-wide analysis of DNA methylation remains technically challenging …
regulation, but genome-wide analysis of DNA methylation remains technically challenging …