Methylated DNA in vertebrates is associated with transcriptional repression and inactive
chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically …

Methylation ofcytosine residues in mammalian genomes is associated with transcriptional
repression and inactive chromatin. It has been shown that methylation of DNA is essential …

Methylation of mammalian DNA can lead to repression of transcription and alteration of
chromatin structure. Recent evidence suggests that both effects are the result of an …

MeCP2 is a chromosomal protein which binds to DNA that is methylated at CpG. In situ
immunofluorescence in mouse cells has shown that the protein is most concentrated in …

We have studied the mechanism by which DNA methyiation inhibits transcription both in ceil-
free nuclear extracts and in the living ceil. Repression of transcription in vitro for four different …

MeCP2 is a chromosomal protein that is concentrated in the centromeric heterochromatin of
mouse cells. In vitro, the protein binds preferentially to DNA containing a single …

MeCP2 is an abundant mammalian protein that binds to methylated CpG. We have found
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …

An important consequence of CpG methylation is the local silencing of gene expression. In
part this can be mediated by direct interference of methylation with the binding of …

DNA methylation is interpreted by a family of methyl-CpG binding domain (MBD) proteins
that repress transcription through recruitment of corepressors that modify chromatin. To …

DNA methylation plays an important role in mammalian development and correlates with
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …