Sex-dependent association between variability in infants' OXTR methylation at birth and negative affectivity at 3 months

S Nazzari, S Grumi, M Villa, F Mambretti… - …, 2022 - Elsevier
Background Sex-specific differences in DNA methylation of the oxytocin receptor gene
(OXTR) have been shown in adults and are related to several mental disorders. Negative …

Associations between childhood maltreatment and DNA methylation of the oxytocin receptor gene in immune cells of mother–newborn dyads

L Ramo-Fernández, AM Gumpp, C Boeck… - Translational …, 2021 - nature.com
The neuropeptide oxytocin (OXT) and its receptor (OXTR) modulate interpersonal
relationships, particularly mother–child interactions. DNA methylation (DNAm) changes of …

Oxytocin receptor gene methylation as a molecular marker for severity of depressive symptoms in affective disorder patients

B Ludwig, L Carlberg, K Kienesberger, P Swoboda… - BMC psychiatry, 2022 - Springer
Background Oxytocin (OXT) is a neuropeptide and hormone involved in emotional
functioning and also seems to play a role in moderating the stress response. Both preclinical …

The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review

C Maud, J Ryan, JE McIntosh, CA Olsson - BMC psychiatry, 2018 - Springer
Abstract Background The neuropeptide Oxytocin (OXT) plays a central role in birthing,
mother-infant bonding and a broad range of related social behaviours in mammals. More …

Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness

JP Gouin, QQ Zhou, L Booij, M Boivin, SM Côté… - Scientific Reports, 2017 - nature.com
Recent models propose deoxyribonucleic acid methylation of key neuro-regulatory genes as
a molecular mechanism underlying the increased risk of mental disorder associated with …

Variation in DNA methylation of the oxytocin receptor gene predicts children's resilience to prenatal stress

I Milaniak, CAM Cecil, ED Barker, CL Relton… - Development and …, 2017 - cambridge.org
Emerging research in epigenetics has shown that there is variability in how environmental
exposures “get under the skin” through mechanisms like DNA methylation to influence gene …

The DNA methylation landscape of the human oxytocin receptor gene (OXTR): data-driven clusters and their relation to gene expression and childhood adversity

S Müller, M Sicorello, D Moser, L Frach… - Translational …, 2023 - nature.com
The oxytocin receptor gene (OXTR) is of interest when investigating the effects of early
adversity on DNA methylation. However, there is heterogeneity regarding the selection of …

[HTML][HTML] Epigenetic modification of the oxytocin receptor gene is associated with emotion processing in the infant brain

KM Krol, MH Puglia, JP Morris, JJ Connelly… - Developmental …, 2019 - Elsevier
The neural capacity to discriminate between emotions emerges early in development,
though little is known about specific factors that contribute to variability in this vital skill …

Perinatal depression and DNA methylation of oxytocin-related genes: a study of mothers and their children

L King, S Robins, G Chen, V Yerko, Y Zhou… - Hormones and …, 2017 - Elsevier
The present study investigated the association of perinatal depression (PD) with differential
methylation of 3 genomic regions among mother and child dyads: exon 3 within the oxytocin …

Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits–A systematic review

M Moerkerke, ML Bonte, N Daniels, V Chubar… - Research in Autism …, 2021 - Elsevier
There is emerging evidence implicating oxytocin receptor gene (OXTR) DNA methylation
(DNAm) in social behaviour. This review investigated its association with autism spectrum …