DNA methylation microarrays can be employed to interrogate cell-type composition in
complex tissues. Here, we expand reference-based deconvolution of blood DNA …

Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …

Genome-wide methylation arrays are powerful tools for assessing cell composition of
complex mixtures. We compare three approaches to select reference libraries for …

Background Cell lineage-specific DNA methylation patterns distinguish normal human
leukocyte subsets and can be used to detect and quantify these subsets in peripheral blood …

Background Confounding due to cellular heterogeneity represents one of the foremost
challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical …

Bulk tissue DNA methylation profiling has been used to examine epigenetic mechanisms
and biomarkers of complex diseases such as cancer. However, heterogeneity of cellular …

Background There has been a long-standing need in biomedical research for a method that
quantifies the normally mixed composition of leukocytes beyond what is possible by simple …

Abstract Background Differentially methylated regions (DMRs) within DNA isolated from
whole blood can be used to estimate the proportions of circulating leukocyte subtypes. We …

Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …

The potential influence of underlying differences in relative leukocyte distributions in studies
involving blood-based profiling of DNA methylation is well recognized and has prompted …