Misregulation of the expression and activity of DNA methyltransferases in cancer
In mammals, DNA methyltransferases DNMT1 and DNMT3's (A, B and L) deposit and
maintain DNA methylation in dividing and nondividing cells. Although these enzymes have …
maintain DNA methylation in dividing and nondividing cells. Although these enzymes have …
Biochemistry and biology of mammalian DNA methyltransferases
DNA methylation is a stable but not irreversible epigenetic signal that silences gene
expression. It has a variety of important functions in mammals, including control of gene …
expression. It has a variety of important functions in mammals, including control of gene …
DNA methyltransferases: a novel target for prevention and therapy
Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …
agents, and the use of various therapeutic combinations, none of the available treatment …
Identification of preferential target sites for human DNA methyltransferases
SH Choi, K Heo, HM Byun, W An, W Lu… - Nucleic acids …, 2011 - academic.oup.com
DNA methyltransferases (DNMTs) play an important role in establishing and maintaining
DNA methylation. Aberrant expression of DNMTs and their isoforms has been found in many …
DNA methylation. Aberrant expression of DNMTs and their isoforms has been found in many …
[HTML][HTML] DNA methyl transferase 1: regulatory mechanisms and implications in health and disease
S Dhe-Paganon, F Syeda, L Park - International journal of …, 2011 - ncbi.nlm.nih.gov
DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …
DNA methyltransferases: from chromatin remodeling to cancer
F Fuks - Medecine Sciences: M/S, 2003 - europepmc.org
DNA methylation plays a pivotal role during development and carcinogenesis and is central
to gene silencing. The recent characterization of the DNA methyltransferases--Dnmt-and …
to gene silencing. The recent characterization of the DNA methyltransferases--Dnmt-and …
Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival
G Egger, S Jeong, SG Escobar… - Proceedings of the …, 2006 - National Acad Sciences
Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for
maintenance of bulk DNA methylation and is essential for mouse development. However …
maintenance of bulk DNA methylation and is essential for mouse development. However …
DNA methyltransferases and their roles in tumorigenesis
W Zhang, J Xu - Biomarker research, 2017 - Springer
DNA methylation plays an important role in gene expression, chromatin stability, and genetic
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …
Expression of DNA methyltransferases DNMT1,3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
S Mizuno, T Chijiwa, T Okamura… - Blood, The Journal …, 2001 - ashpublications.org
Aberrant hypermethylation of tumor suppressor genes plays an important role in the
development of many tumors. Recently identified new DNA methyltransferase (DNMT) …
development of many tumors. Recently identified new DNA methyltransferase (DNMT) …
Methyltransferase DNMT3B in leukemia
H Zhang, H Ying, X Wang - Leukemia & Lymphoma, 2020 - Taylor & Francis
DNA methyltransferases (DNMTs) are highly conserved DNA-modifying enzymes that play
important roles in epigenetic regulation and they are involved in cell proliferation …
important roles in epigenetic regulation and they are involved in cell proliferation …