In mammals, DNA methyltransferases DNMT1 and DNMT3's (A, B and L) deposit and
maintain DNA methylation in dividing and nondividing cells. Although these enzymes have …

DNA methylation is a stable but not irreversible epigenetic signal that silences gene
expression. It has a variety of important functions in mammals, including control of gene …

DNA methyltransferases (DNMTs) play an important role in establishing and maintaining
DNA methylation. Aberrant expression of DNMTs and their isoforms has been found in many …

Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

DNA methylation serves as the principal form of post-replicative epigenetic modification. It is
intricately involved in gene regulation and silencing in eukaryotic cells, making significant …

DNA methylation plays a pivotal role during development and carcinogenesis and is central
to gene silencing. The recent characterization of the DNA methyltransferases--Dnmt-and …

Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for
maintenance of bulk DNA methylation and is essential for mouse development. However …

DNA methylation in mammals is required for embryonic development, X chromosome
inactivation and imprinting. Previous studies have shown that methylation patterns become …

Aberrant hypermethylation of tumor suppressor genes plays an important role in the
development of many tumors. Recently identified new DNA methyltransferase (DNMT) …

DNA methylation plays an important role in gene expression, chromatin stability, and genetic
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …