The extent and role of aberrant DNA methylation in promoter CpG islands (CGIs) have been
extensively studied in leukemia and other malignancies. Still, CGIs represent only a small …

Malignant transformation is frequently associated with disease-specific epigenetic
alterations, but the underlying mechanisms and pathophysiological consequences remain …

We performed a genome-wide analysis of promoter associated CpG island methylation
using methylated CpG island amplification (MCA) coupled to representational differential …

DNA methylation is tightly regulated during development and is stably maintained in healthy
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …

Gains and losses in DNA methylation are prominent features of mammalian cell types. To
gain insight into the mechanisms that promote shifts in DNA methylation and contribute to …

Background Methylation of high-density CpG regions known as CpG Islands (CGIs) has
been widely described as a mechanism associated with gene expression regulation …

DNA methylation primarily occurs at CpG dinucleotides in mammals and is a common
epigenetic mark that plays a critical role in the regulation of gene expression. Profiling DNA …

Epigenetic processes-including DNA methylation-are increasingly seen as having a
fundamental role in chronic diseases like cancer. It is well known that methylation levels at …

The role of CpG island methylation in normal development and cell differentiation is of keen
interest, but remains poorly understood. We performed comprehensive DNA methylation …

Background Aberrant DNA methylation is frequently found in human malignancies including
acute myeloid leukemia (AML). While most studies focus on later disease stages, the onset …