[引用][C] Isolation, physical mapping, and northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2
Methylation ofcytosine residues in mammalian genomes is associated with transcriptional
repression and inactive chromatin. It has been shown that methylation of DNA is essential …
repression and inactive chromatin. It has been shown that methylation of DNA is essential …
Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA
Methylated DNA in vertebrates is associated with transcriptional repression and inactive
chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically …
chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically …
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA
JD Lewis, RR Meehan, WJ Henzel, I Maurer-Fogy… - Cell, 1992 - cell.com
Methylation of mammalian DNA can lead to repression of transcription and alteration of
chromatin structure. Recent evidence suggests that both effects are the result of an …
chromatin structure. Recent evidence suggests that both effects are the result of an …
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
J Boyes, A Bird - Cell, 1991 - cell.com
We have studied the mechanism by which DNA methyiation inhibits transcription both in ceil-
free nuclear extracts and in the living ceil. Repression of transcription in vitro for four different …
free nuclear extracts and in the living ceil. Repression of transcription in vitro for four different …
DNA methylation specifies chromosomal localization of MeCP2
MeCP2 is a chromosomal protein that is concentrated in the centromeric heterochromatin of
mouse cells. In vitro, the protein binds preferentially to DNA containing a single …
mouse cells. In vitro, the protein binds preferentially to DNA containing a single …
Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome
The methyl CpG binding proteins (MeCP1 and MeCP2) are a class of proteins that bind to
templates containing symmetrically methylated CpGs. Using an interspecific backcross …
templates containing symmetrically methylated CpGs. Using an interspecific backcross …
Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs
The effects of DNA methylation on transcription and chromatin structure require that nuclear
factors be able to distinguish methylated and nonmethylated DNA. We describe a nMhyWpG …
factors be able to distinguish methylated and nonmethylated DNA. We describe a nMhyWpG …
DNA binding of methyl-CpG-binding protein MeCP2 in human MCF7 cells
C Koch, WH Strätling - Biochemistry, 2004 - ACS Publications
MeCP2 has been identified as a chromatin-associated protein that recognizes MAR
elements as well as methyl-CpGs. To characterize target sequences of MeCP2 in human …
elements as well as methyl-CpGs. To characterize target sequences of MeCP2 in human …
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
MeCP2 is an abundant mammalian protein that binds to methylated CpG. We have found
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …
Gene silencing by methyl‐CpG‐binding proteins
An important consequence of CpG methylation is the local silencing of gene expression. In
part this can be mediated by direct interference of methylation with the binding of …
part this can be mediated by direct interference of methylation with the binding of …