Eukaryotic gene regulation involves a balance between packaging of the genome into
nucleosomes and enabling access to regulatory proteins and RNA polymerase …

The nucleosome, the structural unit of chromatin, is known to play a central role in regulating
gene transcription from promoters. The last seven years have spawned a vast amount of …

We examined various histone modifications across the promoter and the coding regions of
constitutively active hepatic genes in G0/G1‐enriched, mitotically arrested and α‐amanitin …

Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to
DNA, and chemical modification of histones is a major means by which the cell modulates …

Previous studies in Saccharomyces cerevisiae established that depletion of histone H4
results in the genome-wide transcriptional de-repression of hundreds of genes. To probe the …

Studies in eukaryotes ranging from yeast to mammals indicate that specific chromatin
structures can be inherited following DNA replication via mechanisms acting in cis. Both the …

Nucleosome positioning has been the subject of intense study for many years. The
properties of micrococcal nuclease, the enzyme central to these studies, are discussed. The …

Nucleosome positions on the DNA are determined by the intrinsic affinities of histone
proteins to a given DNA sequence and by the ATP-dependent activities of chromatin …

Gene transcription occurs on a nucleosomal template known as chromatin. The recruitment
of the transcriptional regulators and the transcription machinery to promoter chromatin is …

The entire genome is replicated in a programmed manner, with specific regions undergoing
DNA synthesis at different times in S phase. Active genes generally replicate in early S …