Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
M Ko, HS Bandukwala, J An… - Proceedings of the …, 2011 - National Acad Sciences
The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes
that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5 …
that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5 …
TET2 is essential for survival and hematopoietic stem cell homeostasis
K Shide, T Kameda, H Shimoda, T Yamaji, H Abe… - Leukemia, 2012 - nature.com
Abstract Ten-Eleven-Translocation 2 (TET2) is an enzyme that catalyzes the conversion of 5-
methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state …
methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state …
TET2 in normal and malignant hematopoiesis
RL Bowman, RL Levine - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
The ten-eleven translocation (TET) family of enzymes were originally cloned from the
translocation breakpoint of t (10; 11) in infant acute myeloid leukemia (AML) with …
translocation breakpoint of t (10; 11) in infant acute myeloid leukemia (AML) with …
The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases
E Solary, OA Bernard, A Tefferi, F Fuks, W Vainchenker - Leukemia, 2014 - nature.com
Abstract Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation,
deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event …
deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event …
[HTML][HTML] Non-catalytic roles of Tet2 are essential to regulate hematopoietic stem and progenitor cell homeostasis
K Ito, J Lee, S Chrysanthou, Y Zhao, K Josephs, H Sato… - Cell reports, 2019 - cell.com
The Ten-eleven translocation (TET) enzymes regulate gene expression by promoting DNA
demethylation and partnering with chromatin modifiers. TET2, a member of this family, is …
demethylation and partnering with chromatin modifiers. TET2, a member of this family, is …
[HTML][HTML] Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
K Moran-Crusio, L Reavie, A Shih, O Abdel-Wahab… - Cancer cell, 2011 - cell.com
Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a
significant proportion of patients with myeloid malignancies. Although there are extensive …
significant proportion of patients with myeloid malignancies. Although there are extensive …
Distinct roles for TET family proteins in regulating human erythropoiesis
The ten-eleven translocation (TET) family of proteins plays important roles in a wide range of
biological processes by oxidizing 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine …
biological processes by oxidizing 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine …
TET1 is a tumor suppressor of hematopoietic malignancy
The methylcytosine dioxygenase TET1 ('ten-eleven translocation 1') is an important
regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. The diminished …
regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. The diminished …
TET proteins and 5‐methylcytosine oxidation in hematological cancers
DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon
silencing, genomic imprinting, and X‐chromosome inactivation. Cancer cells display highly …
silencing, genomic imprinting, and X‐chromosome inactivation. Cancer cells display highly …
[HTML][HTML] TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
Loss-of-function mutations affecting one or both copies of the Ten-Eleven-translocation
(TET) 2 gene have been described in various human myeloid malignancies. We report that …
(TET) 2 gene have been described in various human myeloid malignancies. We report that …