DNA methylation is a mechanism for changing the base sequence of DNA without altering
its coding function. As a heritable, yet reversible, epigenetic change, it has the potential of …

It has become clear over the last few years that DNA methylation is essential for normal
embryonic development and that alterations in DNA methylation are very common in cancer …

The successful establishment and stable maintenance of cell identity are critical for
organismal development and tissue homeostasis. Cell identity is provided by epigenetic …

Methylcytosine (5mC) in DNA is produced by post-synthetic modification of cytosine
residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …

DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …

It is not surprising that cancer, a kind of derangement of development, hijacks DNA
methylation, which is necessary for normal mammalian embryogenesis. Both decreases and …

Aberrant DNA methylation is known as an important cause of human cancers, along with
mutations. Although aberrant methylation was initially speculated to be similar to mutations …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …