Potential role for anti‐angiogenic therapy in abdominal aortic aneurysms
Objective Abdominal aortic aneurysm (AAA) is a condition that mainly affects elderly men. At
present, there is no effective medical therapy that can retard aneurysm growth or prevent …
present, there is no effective medical therapy that can retard aneurysm growth or prevent …
Angiogenesis in abdominal aortic aneurysms
OBJECTIVES:: To determine the degree of neovascularisation in the wall of abdominal
aortic aneurysms in comparison to atherosclerotic control aortas, and to correlate the …
aortic aneurysms in comparison to atherosclerotic control aortas, and to correlate the …
Systematic review and meta-analysis of interventions to slow progression of abdominal aortic aneurysm in mouse models
Objective: There are no current effective abdominal aortic aneurysm (AAA) drug therapies.
An important limitation of most preclinical studies is that they test the effect of drugs on AAA …
An important limitation of most preclinical studies is that they test the effect of drugs on AAA …
Pharmacological targets in the treatment of abdominal aortic aneurysms
MP Bergoeing, RW Thompson… - Expert Opinion on …, 2006 - Taylor & Francis
The natural history of an abdominal aortic aneurysm (AAA) is of progressive aortic wall
degeneration occurring over the course of many years, ultimately, culminating in loss of …
degeneration occurring over the course of many years, ultimately, culminating in loss of …
Pharmacotherapy of abdominal aortic aneurysms
J Dawson, E Choke, S Sayed… - Current Vascular …, 2006 - ingentaconnect.com
Aortic aneurysms account for 10,000 deaths annually in the UK, due to rupture. At present
the only effective therapeutic strategy to treat abdominal aortic aneurysms is to surgically …
the only effective therapeutic strategy to treat abdominal aortic aneurysms is to surgically …
Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm
B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …
Current theories and clinical trial evidence for limiting human abdominal aortic aneurysm growth
J Yu, S Liu, J Huang, W Wang - Current drug targets, 2018 - ingentaconnect.com
Background: Abdominal aortic aneurysm (AAA) refers to localized dilation of abdominal
aorta. AAA is largely asymptomatic, but aneurysmal rupture results in a high mortality rate …
aorta. AAA is largely asymptomatic, but aneurysmal rupture results in a high mortality rate …
Pharmacological treatment of abdominal aortic aneurysm
T Miyake, R Morishita - Cardiovascular research, 2009 - academic.oup.com
Abdominal aortic aneurysm (AAA) is a common degenerative condition with high mortality in
older men. Elective surgical or endovascular repair is performed to prevent rupture of large …
older men. Elective surgical or endovascular repair is performed to prevent rupture of large …
[HTML][HTML] Challenges and opportunities in limiting abdominal aortic aneurysm growth
J Golledge, PE Norman, MP Murphy… - Journal of vascular …, 2017 - Elsevier
Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …
Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease
MW Manning, LA Cassis, J Huang… - Vascular …, 2002 - journals.sagepub.com
Abdominal aortic aneurysms (AAA) have a high prevalence in aged populations and are
responsible for a large number of deaths. Despite the widespread nature of the disease …
responsible for a large number of deaths. Despite the widespread nature of the disease …