DNA methylation is an essential part of the epigenome chromatin modification network,
which also comprises several covalent histone protein post-translational modifications. All …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

Methylation of DNA plays an important role in the control of gene expression in higher
eukaryotes. This is largely achieved by the packaging of methylated DNA into chromatin …

Mammalian DNA methyltransferases (DNMTs) establish and maintain genomic DNA
methylation patterns that are required for proper epigenetic regulation of gene expression …

ABSTRACT DNA methylation and histone modifications are two major epigenetic marks in
mammalian cells. Previous studies have revealed that these two mechanisms interact …

Cell type-specific DNA methylation patterns are established during mammalian
development and maintained in adult somatic cells. Understanding how these patterns of 5 …

DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation is an essential epigenetic modification for mammalian embryonic
development and biology. The DNA methylation pattern across the genome, together with …

DNA methylation is a common mechanism of epigenetic regulation in eukaryotic organisms
ranging from fungi to mammals. Genetic studies in model organisms have demonstrated the …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …