DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …

Heritable changes to the transcriptome that are independent to changes in the genome are
defined as epigenetics. DNA methylation and posttranslational modifications of histones …

DNA methylation: A molecular lock Page 1 Dispatch R305 DNA methylation: A molecular lock
Zahava Siegfried and Howard Cedar In mammals, the promoters of expressed genes are …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …

DNA methylation is an epigenetic modification which plays an important role in chromatin
organization and gene expression. DNA methylation can silence genes and repetitive …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

The combinatorial pattern of DNA and histone modifications constitutes an epigenetic
'code'that shapes gene-expression patterns by enabling or restricting the transcriptional …

DNA methylation occurs on cytosines, is catalyzed by DNA methyltransferases (DNMTs),
and is present at high levels in all vertebrates. DNA methylation plays essential roles in …

Research in cancer epigenomics is driven by the development of novel technologies and
the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades …

The disruption of genomic DNA methylation patterns was the first epigeneticabnormality to
be described in human cancer. This imbalance involves thepromoter CpG island …