Polycystic kidney disease (PKD) is a developmental kidney disorder which can be inherited
as either an autosomal dominant trait, with an incidence of 1: 50 to 1: 1000, or as an …

Numerous murine (mouse and rat) models of polycystic kidney disease (PKD) have been
described in which the mutant phenotype results from a spontaneous mutation or …

New insights into the molecular pathophysiology of polycystic kidney disease. Polycystic
kidney diseases are characterized by the progressive expansion of multiple cystic lesions …

Polycystic kidney disease is characterized by localized autonomous cellular proliferation,
compartmentalized fluid accumulation within the cysts, and intraparenchymal fibrosis of the …

Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent, inherited condition
for which there is currently no effective specific clinical therapy. The disease is characterized …

Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive
polycystic kidney disease (ARPKD) are significant causes of morbidity and mortality in …

Polycystic kidney disease (PKD) is a disease of the nephron, characterized by the formation
of multiple renal tubular cysts, leading to endstage renal failure. The most common form is …

Polycystic kidney disease is a common genetic disorder in which fluid-filled cysts displace
normal renal tubules. Here we focus on autosomal dominant polycystic kidney disease …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited
kidney disease that results from mutations in PKD1 or PKD2. The disease is characterized …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common progressive
hereditary kidney disease. In 85–90% of cases, ADPKD results from a mutation in the PKD1 …