Midazolam premedication in children: a comparison of two oral dosage formulations on sedation score and plasma midazolam levels

KK Brosius, CF Bannister - Anesthesia & Analgesia, 2003 - journals.lww.com
We compared two available oral formulations of midazolam with respect to sedation score
and plasma midazolam levels in pediatric surgical patients 2–10 yr old. The commercially …

A comparison of three doses of a commercially prepared oral midazolam syrup in children

CJ Coté, IT Cohen, S Suresh, M Rabb… - Anesthesia & …, 2002 - journals.lww.com
Midazolam is widely used as a preanesthetic medication for children. Prior studies have
used extemporaneous formulations to disguise the bitter taste of IV midazolam and to …

Pediatric pharmacodynamics of midazolam oral syrup

J Marshall, A Rodarte, J Blumer… - The Journal of …, 2000 - Wiley Online Library
In this study, the authors evaluate the pharmacodynamics, safety, and acceptability of a new
cherry‐flavored oral syrup formulation of midazolam. This randomized, double‐blind …

Premedication of children with oral midazolam

CO McMillan, IA Spahr-Schopfer, N Sikich… - Canadian Journal of …, 1992 - Springer
In a randomized, double-blind, placebo-controlled study, the safety, efficacy and feasibility of
oral midazolam premedication in children were evaluated in an ambulatory surgery unit …

Premedication with midazolam in young children: a comparison of four routes of administration

A Kogan, J Katz, R Efrat, LA Eidelman - Pediatric Anesthesia, 2002 - Wiley Online Library
Background: We undertook a study to determine the effects of four routes of administation on
the efficacy of midazolam for premedication. Methods: In a randomized double‐blind study …

Premedication with oral midazolam in children—an assessment of psychomotor function, anxiolysis, sedation and pharmacokinetics

RDM Jones, AR Visram, JP Kornberg… - … and intensive care, 1994 - journals.sagepub.com
We studied 30 children, aged 4 to 12 years, undergoing elective circumcision, premedicated
with midazolam 0.5 mg. kg− 1 and atropine 0.02 mg. kg− 1 by mouth. A modified postbox …

[HTML][HTML] Premedication with midazolam nasal spray: an alternative to oral midazolam in children

RK Verma, A Paswan, A De, S Gupta - Anesthesiology and pain …, 2012 - ncbi.nlm.nih.gov
Background: Midazolam is a water soluble benzodiazepine which is frequently administered
by intravenous and oral routes in our institution. Its nasal spray has become recently …

Sublingual midazolam premedication in children: a dose response study

S Khalil, L Philbrook, M Rabb, K Wagner… - Pediatric …, 1998 - Wiley Online Library
The purpose of this study was to evaluate various doses of sublingual midazolam
premedication in children. In our prospective, double‐blind, placebo‐controlled trial …

Midazolam for premedication in children: nasal vs. rectal administration

C Lejus, M Renaudin, S Testa… - European journal of …, 1997 - Wiley Online Library
The authors compared the acceptance and efficacy of rectal and nasal administration of
midazolam (MDZ) for premedication. Ninety‐five ASA I and II paediatric patients (8 months to …

A novel, palatable paediatric oral formulation of midazolam: pharmacokinetics, tolerability, efficacy and safety

S Salman, EKY Tang, LC Cheung, MN Nguyen… - …, 2018 - Wiley Online Library
Midazolam is one of many bitter drugs where provision of a suitable oral paediatric
formulation, particularly in the pre‐anaesthetic setting, remains a challenge. To overcome …