The imprinted expression of the IGF2 and H19 genes is controlled by the imprinting control
region 1 (ICR1) located at chromosome 11p15. 5. This methylation-sensitive chromatin …

The imprinted expression of the IGF2 and H19 genes is controlled by the imprinting control
region 1 (ICR1) located at chromosome 11p15. 5. DNA methylation defects involving ICR1 …

The IGF2/H19‐imprinting control region (ICR1) functions as an insulator to methylation‐
sensitive binding of CTCF protein, and regulates imprinted expression of IGF2 and H19 in a …

Abstract At chromosome 11p15. 5, the imprinting centre 1 (IC1) controls the parent of origin-
specific expression of the IGF2 and H19 genes. The 5 kb IC1 region contains multiple target …

Hyper-and hypomethylation at the IGF2-H19 imprinting control region (ICR) result in
reciprocal changes in IGF2-H19 expression and the two contrasting growth disorders …

The 11p15 region harbors the IGF2/H19 imprinted domain, implicated in fetal and postnatal
growth. Silver–Russell syndrome (SRS) is characterized by fetal and postnatal growth …

Human chromosome 11p15 comprises two imprinted domains important in the control of
fetal and postnatal growth. Novel studies 1–3 establish that imprinting at one of these, the …

A∼ 2.4-kb imprinting control region (ICR) regulates somatic monoallelic expression of the
Igf2 and H19 genes. This is achieved through DNA methylation-dependent chromatin …

Isolated gain of methylation (GOM) at the IGF2/H19 imprinting control region 1 (ICR1)
accounts for about 10% of patients with BWS. A subset of these patients have genetic …

The reciprocal parent of origin-specific expression of H19 and IGF2 is controlled by the
H19/IGF2: IG-DMR (IC1), whose maternal allele is unmethylated and acts as a CTCF …