Germ line mutations of the VHL gene have been identified as the root cause of this disease.
6 Mutations and/or aberrations of the same gene have been identified in the majority of …

Germline mutations in the VHL tumour suppressor gene may cause a variety of phenotypes
including von Hippel-Lindau (VHL) disease, familial phaeochromocytoma and inherited …

Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …

von Hippel-Lindau disease is a hereditary cancer syndrome predisposing carriers to the
development of a panel of highly vascularized tumors such as central nervous system and …

Abstract The von Hippel-Lindau tumor suppressor gene (VHL), which resides on
chromosome 3p25, is mutated or silenced in> 50% of sporadic clear cell renal cell …

Germline inactivation of the VHL tumor suppressor gene is associated with an increased risk
of clear cell carcinoma of the kidney in the context of von Hippel‐Lindau (VHL) disease. The …

Abstract The Von Hippel–Lindau (VHL) is an inherited neoplasia syndrome caused by the
inactivation of VHL tumor suppressor gene, and somatic mutation of this gene has been …

Germ line mutations in the VHL tumor-suppressor gene cause von Hippel–Lindau (VHL)
disease, a hereditary neoplastic disease associated with clear-cell renal-cell carcinomas …

Mutations in the von Hippel-Lindau (VHL) gene are associated with hereditary and sporadic
clear cell renal carcinoma. VHL acts in a ubiquitin ligase complex regulating hypoxia …

Clear cell carcinoma of the kidney is a major cause of mortality in patients with von Hippel-
Lindau (VHL) disease, which is caused by germ line mutations that inactivate the VHL tumor …