Age determination of wild animals, including pinnipeds, is critical for accurate population
assessment and management. For most pinnipeds, current age estimation methodologies …

Biological ageing and its mechanistic underpinnings are of immense biomedical and
ecological significance. Ageing involves the decline of diverse biological functions and …

Background Global but predictable changes impact the DNA methylome as we age, acting
as a type of molecular clock. This clock can be hastened by conditions that decrease …

Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks,
have been developed for humans and extended to several other species. Three currently …

In wild animal conservation, knowing the age of an individual animal is extremely beneficial.
However, estimating the age is difficult for many species. Recently, epigenetics-based …

As the population ages, interest in identifying biomarkers of healthy aging and developing
antiaging interventions has increased. DNA methylation has emerged as a potentially …

Age-related changes to cytosine methylation have been extensively characterized across
the mammalian family. Some cytosines that are conserved across mammals exhibit age …

Epigenetic clocks for mice were generated based on deep-sequencing analysis of the
methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by …

Epigenetic clocks are calculated by combining DNA methylation states across select CpG
sites to estimate biologic age, and have been noted as the most successful markers of …

Methylation at CpG sites is a critical epigenetic modification in mammals. Altered DNA
methylation has been suggested to be a central mechanism in development, some disease …