Genome-wide methylation patterns in normal and uniparental early mouse embryos
SC Barton, KL Arney, W Shi, A Niveleau… - Human Molecular …, 2001 - academic.oup.com
In the normal diploid mouse embryo, active demethylation of the paternal genome but not of
the maternal genome occurs within only a few hours and in a highly coordinated fashion as …
the maternal genome occurs within only a few hours and in a highly coordinated fashion as …
Active demethylation of the paternal genome in the mouse zygote
J Oswald, S Engemann, N Lane, W Mayer, A Olek… - Current Biology, 2000 - cell.com
DNA methylation is essential for the control of a number of biological mechanisms in
mammals [1]. Mammalian development is accompanied by two major waves of genome …
mammals [1]. Mammalian development is accompanied by two major waves of genome …
Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development
M Monk, M Boubelik, S Lehnert - Development, 1987 - journals.biologists.com
This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …
occurring during embryonic development. The egg genome is strikingly undermethylated …
Methylation dynamics in the early mammalian embryo: implications of genome reprogramming defects for development
T Haaf - DNA methylation: development, genetic disease and …, 2006 - Springer
In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …
parent-specific epigenetic reprogramming during preimplantation development. The …
Aberrant methylation patterns at the two‐cell stage as an indicator of early developmental failure
W Shi, T Haaf - Molecular Reproduction and Development …, 2002 - Wiley Online Library
The fertilized mouse egg actively demethylates the paternal genome within a few hours after
fertilization, whereas the maternal genome is only passively demethylated by a replication …
fertilization, whereas the maternal genome is only passively demethylated by a replication …
Hypomethylation of paternal DNA in the late mouse zygote is not essential for development.
Z Polanski, N Motosugi, C Tsurumi… - International …, 2008 - search.ebscohost.com
Global demethylation of DNA which marks the onset of development occurs asynchronously
in the mouse; paternal DNA is demethylated at the zygote stage, whereas maternal DNA is …
in the mouse; paternal DNA is demethylated at the zygote stage, whereas maternal DNA is …
Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos
W Shi, F Dirim, E Wolf, V Zakhartchenko… - Biology of …, 2004 - academic.oup.com
Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …
Dynamic reprogramming of DNA methylation in the early mouse embryo
Dynamic epigenetic modification of the genome occurs during early development of the
mouse. Active demethylation of the paternal genome occurs in the zygote, followed by …
mouse. Active demethylation of the paternal genome occurs in the zygote, followed by …
Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote
The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …
DNA methylation pattern in human zygotes and developing embryos
H Fulka, M Mrazek, O Tepla, J Fulka - Reproduction, 2004 - rep.bioscientifica.com
We report on observations of the global methylation/demethylation pattern of both pronuclei
in human zygotes and in early embryos up to the blastocyst stage. Our results demonstrate …
in human zygotes and in early embryos up to the blastocyst stage. Our results demonstrate …
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