DNA methylation analysis: a review of current methodologies
EJ Oakeley - Pharmacology & therapeutics, 1999 - Elsevier
The relationship between levels of DNA methylation and gene activity has been known for
some time. Many of the early procedures developed gave only somewhat limited information …
some time. Many of the early procedures developed gave only somewhat limited information …
DNA methylation properties: consequences for pharmacology
M Szyf - Trends in pharmacological sciences, 1994 - cell.com
The aim of pharmacology has traditionally been to develop compounds that could mimic,
activate or antagonize the molecules that control and regulate the physiological state of an …
activate or antagonize the molecules that control and regulate the physiological state of an …
DNA methylation: a profile of methods and applications
MF Fraga, M Esteller - Biotechniques, 2002 - Taylor & Francis
Ever since methylcytosine was found in genomic DNA, this epigenetic alteration has
become a center of scientific attraction, especially because of its relation to gene silencing in …
become a center of scientific attraction, especially because of its relation to gene silencing in …
5-Methylcytosine as a marker for the monitoring of DNA methylation
J Havliš, M Trbušek - Journal of Chromatography B, 2002 - Elsevier
The extent of the DNA methylation of genomic DNA as well as the methylation pattern of
many gene-regulatory areas are important aspects with regard to the state of genetic …
many gene-regulatory areas are important aspects with regard to the state of genetic …
[图书][B] DNA methylation
J Tost - 2009 - Springer
Epigenetics can be defined as the study of heritable changes in gene expression without
alteration of the DNA sequence itself. This means that epigenetic variants are stable …
alteration of the DNA sequence itself. This means that epigenetic variants are stable …
25 DNA Methylation
S Hattman - The enzymes, 1981 - Elsevier
Publisher Summary Almost all biological macromolecules undergo some form of processing
event subsequent to their biosynthesis. These processes such as cleaving, phosphorylation …
event subsequent to their biosynthesis. These processes such as cleaving, phosphorylation …
Measurement of genome wide DNA methylation by reversed-phase high-performance liquid chromatography
BH Ramsahoye - Methods, 2002 - Elsevier
A method to determine the extent of cytosine methylation in DNA is described. The
technique involves the enzymatic hydrolysis of DNA to its deoxyribonucleotide components …
technique involves the enzymatic hydrolysis of DNA to its deoxyribonucleotide components …
Identification of DNA methylation differences during tumorigenesis by methylation-sensitive arbitrarily primed polymerase chain reaction
The ability to detect methylation changes associated with oncogenic transformation is of
critical importance in understanding how DNA methylation may contribute to tumorigenesis …
critical importance in understanding how DNA methylation may contribute to tumorigenesis …
An improved version of the DNA Methylation database (MethDB)
C Amoreira, W Hindermann, C Grunau - Nucleic acids research, 2003 - academic.oup.com
Cytosine methylation is a characteristic property of prokaryotic and eukaryotic genomes. In
the latter, it is indispensable for a healthy development of the organism and uncontrolled …
the latter, it is indispensable for a healthy development of the organism and uncontrolled …
Gene methylation patterns and expression
J Yisraeli, M Szyf - DNA methylation: biochemistry and biological …, 1984 - Springer
Three basic approaches have been employed in the study of the effect of DNA methylation
of particular genes on their expression. One approach uses chemicals that cause …
of particular genes on their expression. One approach uses chemicals that cause …