Anxiogenic effects of cocaine withdrawal in zebrafish

MA López-Patiño, L Yu, H Cabral, IV Zhdanova - Physiology & behavior, 2008 - Elsevier
Continued usage of cocaine is determined by genetic, conditioned and homeostatic factors,
while it is reinforced by drug-induced reward and the emotionally negative state of drug …

Gender differences in zebrafish responses to cocaine withdrawal

MAL Patiño, L Yu, BK Yamamoto, IV Zhdanova - Physiology & behavior, 2008 - Elsevier
The acute responses to cocaine and its withdrawal contribute to cocaine dependence and
potentiate relapse, with gender being one of the genetic factors affecting the outcome. Here …

Modeling withdrawal syndrome in zebrafish

J Cachat, P Canavello, M Elegante, B Bartels… - Behavioural brain …, 2010 - Elsevier
The zebrafish (Danio rerio) is rapidly becoming a popular model species in behavioral
neuroscience research. Zebrafish behavior is robustly affected by environmental and …

Zebrafish models to study drug abuse-related phenotypes

A Stewart, K Wong, J Cachat, S Gaikwad, E Kyzar… - 2011 - degruyter.com
Mounting evidence implicates the zebrafish (Danio rerio) as a promising model species for
reward and addiction research. Modeling drug abuse-related behavior in both adult and …

Behavioral screening for cocaine sensitivity in mutagenized zebrafish

T Darland, JE Dowling - Proceedings of the National …, 2001 - National Acad Sciences
Understanding the molecular basis of addiction could be greatly aided by using forward
genetic manipulation to lengthen the list of candidate genes involved in this complex …

The zebrafish as a model system for assessing the reinforcing properties of drugs of abuse

J Ninkovic, L Bally-Cuif - Methods, 2006 - Elsevier
Recent reports make use of the zebrafish to study complex behavior such as addiction,
anxiety, or learning and memory. We have established reliable tests and appropriate …

The effects of cocaine on heart rate and electrocardiogram in zebrafish (Danio rerio)

EJ Mersereau, SL Poitra, A Espinoza… - … and Physiology Part C …, 2015 - Elsevier
Zebrafish (Danio rerio) have been used as a model organism to explore the genetic basis for
responsiveness to addictive drugs like cocaine. However, very little is known about how the …

Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways

LJM Kily, YCM Cowe, O Hussain… - Journal of …, 2008 - journals.biologists.com
Addiction is a complex psychiatric disorder considered to be a disease of the brain's natural
reward reinforcement system. Repeated stimulation of thereward'pathway leads to adaptive …

From the cover: zebrafish larvae are insensitive to stimulation by cocaine: importance of exposure route and toxicokinetics

KT Kirla, KJ Groh, AE Steuer, M Poetzsch… - Toxicological …, 2016 - academic.oup.com
Zebrafish (Danio rerio) larvae have been suggested as vertebrate model to complement or
even replace mammals for rapidly assessing behavioral effects of psychoactive drugs. Yet …

Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety

Z Bencan, D Sledge, ED Levin - Pharmacology Biochemistry and Behavior, 2009 - Elsevier
Zebrafish are becoming more widely used to study neurobehavioral pharmacology. We
have developed a method to assess novel environment diving behavior of zebrafish as a …