DNA in somatic tissue is characterized by a bimodal pattern of methylation, which is
established in the animal through a series of developmental events 1. In the mouse blastula …

Cytosine methylation is an epigenetic mechanism in eukaryotes that is often associated with
stable transcriptional silencing, such as in X-chromosome inactivation and genomic …

The majority of mammalian promoters are CpG islands; regions of high CG density that
require protection from DNA methylation to be functional. Importantly, how sequence …

Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …

Background DNA methylation is thought to play an important role in the regulation of
mammalian gene expression, partly based on the observation that a lack of CpG island …

I respectfully propose this neologism because it serves to formally unite the study of DNA
methylation with the power of modern genomics. At this writing, the word does not appear in …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

DNA methylation is an essential epigenetic mark whose role in gene regulation and its
dependency on genomic sequence and environment are not fully understood. In this study …

Epigenetics refers to covalent modifications of DNA and core histones that regulate gene
activity without altering DNA sequence. To date, the best‐characterized DNA modification …

Epigenetics describes the heritable changes in gene function that occur independently to
the DNA sequence. The molecular basis of epigenetic gene regulation is complex, but …