Adjacent CpG sites in mammalian genomes can be co-methylated owing to the processivity
of methyltransferases or demethylases, yet discordant methylation patterns have also been …

The underlying basis of the malignant progression of astrocytomas is a specific and
cumulative series of genetic alterations, most of which are confined to high-grade tumors. In …

CpG island hypermethylation is known to be associated with gene silencing in cancer. This
epigenetic event is generally accepted as a stochastic process in tumor cells resulting from …

Hypermethylation of CpG islands is a common epigenetic alteration associated with cancer.
Global patterns of hypermethylation are tumor-type specific and nonrandom. The biological …

In cancer cells, aberrant DNA methylation is commonly associated with transcriptional
alterations, including silencing of tumor suppressor genes. However, multiple epigenetic …

Human cancers are caused by multiple mechanisms. Research in the last 30 years has
firmly established the roles of a group of genes including oncogenes, tumor suppressor …

Aberrant DNA hypomethylation may play an important role in the growth rate of glioblastoma
(GBM), but the functional impact on transcription remains poorly understood. We assayed …

For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur
in cancer, including hypomethylation of oncogenes and hypermethylation of tumor …

Extensive changes in DNA methylation are common in cancer and may contribute to
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …

We report a new mechanism in carcinogenesis involving coordinate long-range epigenetic
gene silencing. Epigenetic silencing in cancer has always been envisaged as a local event …