DNA methylation loss occurs frequently in cancer genomes, primarily within lamina-
associated, late-replicating regions termed partially methylated domains (PMDs). We …

Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with
many human tumour types. New techniques have been developed to perform genome-wide …

Human cancer genomes are characterized by widespread aberrations in DNA methylation
patterns including DNA hypomethylation of mostly repetitive sequences and …

Glioblastoma is characterized by widespread genetic and transcriptional heterogeneity, yet
little is known about the role of the epigenome in glioblastoma disease progression. Here …

It is now clear that aberrant DNA methylation observed in cancer cells is not restricted to a
few CpG islands, but affects multiple loci. When this epigenetic event occurs at the 5′-end …

Global loss of DNA methylation has been known for decades as an epigenomic aberration
associated with carcinogenesis and cancer progression. Loss of DNA methylation affects …

Both genome-wide genetic and epigenetic alterations are fundamentally important for the
development of cancers, but the interdependence of these aberrations is poorly understood …

DNA methylation at the promoter of a gene is presumed to render it silent, yet a sizable
fraction of genes with methylated proximal promoters exhibit elevated expression. Here, we …

Restriction landmark genomic scanning applied to a broad variety of cancer types can
disclose tumour-specific and tumour-type–specific global methylation profiles. This and …

CpG‐island hypermethylation of gene promoters is a frequent mechanism for gene
inactivation in tumors. Many neuroblastomas have hypermethylation and down‐regulation of …