Although promoter-associated CpG islands have been established as targets of DNA
methylation changes in cancer, previous studies suggest that epigenetic dysregulation …

Densely methylated DNA associates with transcriptionally repressive chromatin
characterized by the presence of underacetylated histones 1, 2. Recently, these two …

Patterns of amino acid conservation have served as a tool for understanding protein
evolution. The same principles have also found broad application in human genomics …

We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the
context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples …

DNA methylation is part of the epigenetic gene regulation complex, which is relevant for the
pathogenesis of cancer. We performed a genome-wide search for methylated CpG islands …

CpG islands (CGIs) are one of the most widely studied regulatory features of the human
genome, with critical roles in development and disease. Despite such significance and the …

Aberrant methylation of CpG islands in gene promoters often represents an early clonal
event in carcinogenesis. Accordingly, defining methylation profiles may be useful for …

Gene silencing via promoter CpG island hypermethylation offers tumor cells growth
advantages. This epigenetic event is pharmacologically reversible, and uncovering a unique …

Aberrant DNA methylation of CpG islands has been widely observed in human colorectal
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …

CpG island methylation within promoters is known to silence individual genes in cancer. The
involvement of this process in silencing gene pairs controlled by bidirectional promoters is …