Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some …

Background High-grade soft tissue sarcomas are a heterogeneous, complex group of
aggressive malignant tumors showing mesenchymal differentiation. Recently, soft tissue …

Tumor classification has evolved over the last decades with technical progress contributing
much to our current concepts. Among diagnostic hallmarks, novelties were immunostaining …

DNA methylation‐based machine learning algorithms represent powerful diagnostic tools
that are currently emerging for several fields of tumour classification. For various reasons …

Aberrant methylation of genomic DNA has been reported in many cancers. Specific DNA
methylation patterns have been shown to provide clinically useful prognostic information …

Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …

Aberrant DNA methylation of CpG sites is among the earliest and most frequent alterations
in cancer. Several studies suggest that aberrant methylation occurs in a tumour type-specific …

Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system …

Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …

Undifferentiated solid tumors with small blue round cell histology and expression of CD99
mostly resemble Ewing sarcoma. However, they also may include other tumors such as …