Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms

J Frösen, J Cebral, AM Robertson, T Aoki - Neurosurgical focus, 2019 - thejns.org
OBJECTIVE Unruptured intracranial aneurysms (UIAs) are relatively common lesions that
may cause devastating intracranial hemorrhage, thus producing considerable suffering and …

CFD: computational fluid dynamics or confounding factor dissemination? The role of hemodynamics in intracranial aneurysm rupture risk assessment

J Xiang, VM Tutino, KV Snyder… - American Journal of …, 2014 - Am Soc Neuroradiology
Image-based computational fluid dynamics holds a prominent position in the evaluation of
intracranial aneurysms, especially as a promising tool to stratify rupture risk. Current …

Hemodynamic stress, inflammation, and intracranial aneurysm development and rupture: a systematic review

F Signorelli, S Sela, L Gesualdo, S Chevrel, F Tollet… - World neurosurgery, 2018 - Elsevier
Background There seems to be a pathogenetic link between hemodynamics and
inflammatory arterial wall alteration leading to the development and rupture of intracranial …

Role of fluid dynamics and inflammation in intracranial aneurysm formation

AS Turjman, F Turjman, ER Edelman - Circulation, 2014 - Am Heart Assoc
374 Circulation January 21, 2014 to vascular aneurysms, we surmise that aneurysm-
protective flows and wall states maintain vascular homeostasis throughout the cerebral tree …

The association between hemodynamics and wall characteristics in human intracranial aneurysms: a review

H Rajabzadeh-Oghaz, AH Siddiqui, A Asadollahi… - Neurosurgical …, 2021 - Springer
Hemodynamics plays a key role in the natural history of intracranial aneurysms (IAs).
However, studies exploring the association between aneurysmal hemodynamics and the …

Potential therapeutic strategies for intracranial aneurysms targeting aneurysm pathogenesis

Z Liu, K Ajimu, N Yalikun, Y Zheng, F Xu - Frontiers in Neuroscience, 2019 - frontiersin.org
Subarachnoid hemorrhage resulting from intracranial aneurysms (IAs) is associated with
high rates of morbidity and mortality. Although trigger mechanisms in the pathogenesis of …

High WSS or low WSS? Complex interactions of hemodynamics with intracranial aneurysm initiation, growth, and rupture: toward a unifying hypothesis

H Meng, VM Tutino, J Xiang… - American Journal of …, 2014 - Am Soc Neuroradiology
Increasing detection of unruptured intracranial aneurysms, catastrophic outcomes from
subarachnoid hemorrhage, and risks and cost of treatment necessitate defining objective …

Multivariate analysis of hemodynamic parameters on intracranial aneurysm initiation of the internal carotid artery

K Sunderland, J Jiang - Medical engineering & physics, 2019 - Elsevier
Although fluctuating hemodynamic wall stressors are known to impact intracranial
aneurysms (IA) initiation, specificity of those stressors has not been evaluated. In this study …

Hemodynamic mechanisms underlying cerebral aneurysm pathogenesis

DL Penn, RJ Komotar, ES Connolly - Journal of Clinical Neuroscience, 2011 - Elsevier
Intracranial aneurysms and associated subarachnoid hemorrhage (SAH) are predominant
cerebrovascular disorders that present a significant public health risk through high rates of …

The link between hemodynamics and wall structure in cerebral aneurysms

X Duan - 2016 - search.proquest.com
Intracranial aneurysms (IAs) are pathological enlargements of the walls of cerebral arteries.
Rupture of aneurysms causes 80% of subarachnoid hemorrhages. It is generally accepted …