Molecular alterations associated with aneurysmal remodeling are localized in the high hemodynamic stress region of a created carotid bifurcation
OBJECTIVE Although elevated hemodynamics has been speculated to play a key role in
intracranial aneurysm (IA) initiation, little is known about the specific hemodynamic …
intracranial aneurysm (IA) initiation, little is known about the specific hemodynamic …
Role of hemodynamic forces in unruptured intracranial aneurysms: an overview of a complex scenario
Background An understanding of the natural history of unruptured intracranial aneurysms
(IAs) has always played a critical role in presurgical or endovascular planning, to avoid …
(IAs) has always played a critical role in presurgical or endovascular planning, to avoid …
Characteristic effect of wall elasticity on flow instability and wall shear stress of a full-scale, patient-specific aneurysm model in the middle cerebral artery: An …
The mechanisms underlying the growth and rupture of aneurysms are poorly understood.
Although the wall shear stress (WSS) in elastic aneurysm models is examined using fluid …
Although the wall shear stress (WSS) in elastic aneurysm models is examined using fluid …
Can biomechanical analysis shed some light on aneurysmal pathophysiology? Preliminary study on ex vivo cerebral arterial walls
L Brunasso, G Alotta, M Zingales, DG Iacopino… - Clinical …, 2021 - Elsevier
Background The pathophysiology of cerebral aneurysm is complex and poorly understood,
and it can have the most catastrophic clinical presentation. Flow dynamics is a key player in …
and it can have the most catastrophic clinical presentation. Flow dynamics is a key player in …
E-016 a comparative review of the hemodynamics and pathogenesis of cerebral and abdominal aortic aneurysms: lessons to learn from each other
Introduction/purpose Cerebral aneurysms (CAs) and abdominal aortic aneurysms (AAAs)
are both degenerative vascular pathologies that manifest as an abnormal dilation of the …
are both degenerative vascular pathologies that manifest as an abnormal dilation of the …
Wall shear stress in intracranial aneurysms and adjacent arteries☆
F Wang, B Xu, Z Sun, C Wu… - Neural regeneration …, 2013 - journals.lww.com
Hemodynamic parameters play an important role in aneurysm formation and growth.
However, it is difficult to directly observe a rapidly growing de novo aneurysm in a patient. To …
However, it is difficult to directly observe a rapidly growing de novo aneurysm in a patient. To …
Patient-specific models of cerebral aneurysm evolution
A Selimovic - 2013 - ora.ox.ac.uk
A cerebral aneurysm (CA) is an abnormal distension of the wall of an artery in the brain,
which results from arterial wall weakening. CAs are poorly understood, but are believed to …
which results from arterial wall weakening. CAs are poorly understood, but are believed to …
Novel high-throughput in vitro model for identifying hemodynamic-induced inflammatory mediators of cerebral aneurysm formation
Cerebral aneurysms are thought to develop at locations of hemodynamic shear stress, via
an inflammatory process. The molecular mechanism that links shear stress to inflammation …
an inflammatory process. The molecular mechanism that links shear stress to inflammation …
Intracranial aneurysms: from vessel wall pathology to therapeutic approach
An aneurysm is a focal dilatation of an arterial blood vessel. Luminal forces, such as high
blood flow, shear stress and turbulence, are implicated in the pathogenesis of intracranial …
blood flow, shear stress and turbulence, are implicated in the pathogenesis of intracranial …
Influence of intracranial aneurysm-to-parent vessel size ratio on hemodynamics and implication for rupture: results from a virtual experimental study
OBJECTIVE: The effectiveness of intracranial aneurysm (IA) size as a predictor for rupture
has been debated. We recently performed a retrospective analysis of IA morphology and …
has been debated. We recently performed a retrospective analysis of IA morphology and …