von Hippel-Lindau (vHL) disease is a heritable multisystem cancer syndrome that is
associated with a germ line mutation of the vHL tumor suppressor gene on the short arm of …

Renal tumor heterogeneity studies have utilized the von Hippel-Lindau VHL gene to classify
disease into molecularly defined subtypes to examine associations with etiologic risk factors …

The majority of kidney cancers are caused by the mutation of the von Hippel-Lindau (VHL)
tumor suppressor gene. VHL protein (pVHL) is part of an E3 ubiquitin ligase complex called …

Recent studies of a relatively rare hereditary cancer syndrome, von Hippel-Lindau (VHL)
disease, have shed new light on the molecular pathogenesis of kidney cancer and, perhaps …

Protein-coding mutations in clear cell renal cell carcinoma (ccRCC) have been extensively
characterized, frequently involving inactivation of the von Hippel–Lindau (VHL) tumor …

We have previously reported on the analysis of germ‐line mutations in Japanese von Hippel‐
Lindau disease (VHL) patients and found mutations in 26 families. We have now extended …

Abstract Background The VHL protein (pVHL) is a multiadaptor protein that interacts with
more than 30 different binding partners involved in many oncogenic processes. About 70 …

Although hereditary kidney cancer syndrome accounts for approximately five percent of all
kidney cancers, the mechanistic insight into tumor development in these rare conditions has …

Purpose: Somatic mutations of the von Hippel-Lindau tumor suppressor gene VHL and loss
of heterozygosity of 3p25 to 26 have been well analyzed in renal cell carcinoma but it is not …

Inheritance of a defective copy of the von Hippel-Lindau (VHL) gene leads to the most
common cause of inherited renal cell carcinoma (RCC). In addition, most patients with …