Background Development of human tissue is influenced by a combination of intrinsic
biological signals and extrinsic environmental stimuli, both of which are mediated by …

In early embryos, DNA methylation is remodelled to initiate the developmental program but
for mostly unknown reasons, methylation marks are acquired unequally between embryonic …

Background Epidemiological studies demonstrate that foetal growth restriction and low birth
weight affect long-term health. Derangements in tissue-specific epigenetic programming of …

Human preimplantation development is characterized by low developmental rates that are
poorly understood. Early mammalian embryogenesis is characterized by a major phase of …

DNA methylation is globally reprogrammed after fertilization, and as a result, the parental
genomes have similar DNA-methylation profiles after implantation except at the germline …

Remodelling the methylome is a hallmark of mammalian development and cell
differentiation. However, current knowledge of DNA methylation dynamics in human tissue …

Background Changes in DNA methylation in the mammalian genome during development
are frequent events and play major roles regulating gene expression and other …

DNA methylation is an essential epigenetic mechanism involved in many essential cellular
processes. During development epigenetic reprograming takes place during gametogenesis …

Differential methylation of the two parental genomes in placental mammals is essential for
genomic imprinting and embryogenesis. To systematically study this epigenetic process, we …

DNA methylation plays important roles during development. However, the DNA methylation
reprogramming of functional elements has not been fully investigated during mammalian …