Tet family proteins and 5-hydroxymethylcytosine in development and disease
L Tan, YG Shi - Development, 2012 - journals.biologists.com
Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine,
5mC) has emerged as an important epigenetic modification that plays essential roles in …
5mC) has emerged as an important epigenetic modification that plays essential roles in …
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
Ten-eleven translocation 1–3 (Tet1–3) proteins have recently been discovered in
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …
[HTML][HTML] Genomic distribution and possible functions of DNA hydroxymethylation in the brain
L Wen, F Tang - Genomics, 2014 - Elsevier
Abstract DNA methylation (5-methylcytosine, 5mC) is involved in many cellular processes
and emerges as an important epigenetic player in brain development and memory …
and emerges as an important epigenetic player in brain development and memory …
[HTML][HTML] Hydroxymethylation of DNA: an epigenetic marker
R Richa, RP Sinha - EXCLI journal, 2014 - ncbi.nlm.nih.gov
DNA methylation, an epigenetic mechanism is claimed to play essential roles in
development, aging and disease over the past few decades. Cytosines (C) were known to …
development, aging and disease over the past few decades. Cytosines (C) were known to …
[HTML][HTML] TET (Ten-eleven translocation) family proteins: Structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
5-Hydroxymethylcytosine: an epigenetic mark frequently deregulated in cancer
LI Kroeze, BA van der Reijden, JH Jansen - Biochimica et Biophysica Acta …, 2015 - Elsevier
Abstract The epigenetic mark 5-hydroxymethylcytosine (5hmC) has gained interest since
2009, when it was discovered that Ten-Eleven-Translocation (TET) proteins catalyze the …
2009, when it was discovered that Ten-Eleven-Translocation (TET) proteins catalyze the …
Advances in DNA methylation: 5-hydroxymethylcytosine revisited
C Dahl, K Grønbæk, P Guldberg - Clinica chimica acta, 2011 - Elsevier
Mammalian DNA contains two modified cytosine bases; 5-methylcytosine (5mC) and 5-
hydroxymethylcytosine (5hmC). Both of these have been known for decades but have …
hydroxymethylcytosine (5hmC). Both of these have been known for decades but have …
[HTML][HTML] Tet family of 5-methylcytosine dioxygenases in mammalian development
H Zhao, T Chen - Journal of human genetics, 2013 - nature.com
Methylation of cytosines is a major epigenetic modification in mammalian genomes. The
levels and patterns of DNA methylation are the results of the opposing actions of methylating …
levels and patterns of DNA methylation are the results of the opposing actions of methylating …
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …
DNA elements, regulating transcription and establishing cellular identity. The recent …
[HTML][HTML] Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers
DNA methylation at the 5-position of cytosines (5mC) represents an important epigenetic
modification involved in tissue differentiation and is frequently altered in cancer. Recent …
modification involved in tissue differentiation and is frequently altered in cancer. Recent …