[PDF][PDF] Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency
BA Caldwell, MY Liu, RD Prasasya, T Wang… - Molecular cell, 2021 - cell.com
Active DNA demethylation via ten-eleven translocation (TET) family enzymes is essential for
epigenetic reprogramming in cell state transitions. TET enzymes catalyze up to three …
epigenetic reprogramming in cell state transitions. TET enzymes catalyze up to three …
Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a
The ten-eleven translocation family of proteins (Tet1/2/3, Tets) converts 5-methylcytosine
(5mC) to 5-hydroxymethylcytosine (5hmC), which can be further oxidized and repaired by …
(5mC) to 5-hydroxymethylcytosine (5hmC), which can be further oxidized and repaired by …
[PDF][PDF] Isoform switch of TET1 regulates DNA demethylation and mouse development
The methylcytosine oxidase TET proteins play important roles in DNA demethylation and
development. However, it remains elusive how exactly they target substrates and execute …
development. However, it remains elusive how exactly they target substrates and execute …
Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine
SG Jin, S Kadam, GP Pfeifer - Nucleic acids research, 2010 - academic.oup.com
ABSTRACT DNA cytosine-5 methylation is a well-studied epigenetic pathway implicated in
gene expression control and disease pathogenesis. Different technologies have been …
gene expression control and disease pathogenesis. Different technologies have been …
[HTML][HTML] Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation
Summary TET proteins oxidize 5-methylcytosine (5mC) on DNA and play important roles in
various biological processes. Mutations of TET2 are frequently observed in myeloid …
various biological processes. Mutations of TET2 are frequently observed in myeloid …
5-Hydroxymethylcytosine: generation, fate, and genomic distribution
5-Methylcytosine (5mC) can be converted to 5-hydroxymethylcytosine (5hmC) in
mammalian cells by the ten-eleven translocation (Tet) family of dioxygenases. While 5mC …
mammalian cells by the ten-eleven translocation (Tet) family of dioxygenases. While 5mC …
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
M Ko, HS Bandukwala, J An… - Proceedings of the …, 2011 - National Acad Sciences
The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes
that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5 …
that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5 …
[HTML][HTML] Loss of nuclear localization of TET2 in colorectal cancer
Y Huang, G Wang, Z Liang, Y Yang, L Cui, CY Liu - Clinical epigenetics, 2016 - Springer
Hydroxymethylcytosine (5hmC) is lost in multiple human cancers, including colorectal
cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but …
cancer (CRC). Decreased ten-eleven translocation 1 (TET1) messenger RNA (mRNA), but …
[HTML][HTML] Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1
C Liu, L Liu, X Chen, J Shen, J Shan, Y Xu, Z Yang… - PloS one, 2013 - journals.plos.org
DNA methylation is an important epigenetic modification and is frequently altered in cancer.
Convert of 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5 hmC) by ten-eleven …
Convert of 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5 hmC) by ten-eleven …
TET2 is essential for survival and hematopoietic stem cell homeostasis
K Shide, T Kameda, H Shimoda, T Yamaji, H Abe… - Leukemia, 2012 - nature.com
Abstract Ten-Eleven-Translocation 2 (TET2) is an enzyme that catalyzes the conversion of 5-
methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state …
methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state …