DNA methylation: TET proteins—guardians of CpG islands?
K Williams, J Christensen, K Helin - EMBO reports, 2012 - embopress.org
DNA methylation is involved in key cellular processes, including X‐chromosome
inactivation, imprinting and transcriptional silencing of specific genes and repetitive …
inactivation, imprinting and transcriptional silencing of specific genes and repetitive …
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
T Pfaffeneder, F Spada, M Wagner… - Nature chemical …, 2014 - nature.com
Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-
methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5 …
methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5 …
TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer
IF López-Moyado, M Ko, PG Hogan… - Annual Review of …, 2024 - annualreviews.org
Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine)
has a profound impact on chromatin structure, gene expression and maintenance of cellular …
has a profound impact on chromatin structure, gene expression and maintenance of cellular …
Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development
D Nettersheim, LC Heukamp, F Fronhoffs, MJ Grewe… - PloS one, 2013 - journals.plos.org
During mammalian development the fertilized zygote and primordial germ cells lose their
DNA methylation within one cell cycle leading to the concept of active DNA demethylation …
DNA methylation within one cell cycle leading to the concept of active DNA demethylation …
Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution
5-Methylcytosine can be converted to 5-hydroxymethylcytosine (5hmC) in mammalian DNA
by the ten-eleven translocation (TET) enzymes. We introduce oxidative bisulfite sequencing …
by the ten-eleven translocation (TET) enzymes. We introduce oxidative bisulfite sequencing …
TET1 is a tumor suppressor of hematopoietic malignancy
The methylcytosine dioxygenase TET1 ('ten-eleven translocation 1') is an important
regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. The diminished …
regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. The diminished …
[PDF][PDF] Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development
MM Dawlaty, A Breiling, T Le, G Raddatz, MI Barrasa… - Developmental cell, 2013 - cell.com
Summary Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for …
hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for …
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation
The TET (ten–eleven translocation) family of α-ketoglutarate (α-KG)-dependent
dioxygenases catalyzes the sequential oxidation of 5-methylcytosine (5mC) to 5 …
dioxygenases catalyzes the sequential oxidation of 5-methylcytosine (5mC) to 5 …
[PDF][PDF] The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells
Epigenetic regulation of lineage-specific genes is important for the differentiation and
function of T cells. Ten-eleven translocation (Tet) proteins catalyze 5-methylcytosine (5mC) …
function of T cells. Ten-eleven translocation (Tet) proteins catalyze 5-methylcytosine (5mC) …