[HTML][HTML] Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
DNA methylation, which is modulated by both genetic factors and environmental exposures,
may offer a unique opportunity to discover novel biomarkers of disease-related brain …
may offer a unique opportunity to discover novel biomarkers of disease-related brain …
Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
[HTML][HTML] DNA methylation and brain structure and function across the life course: A systematic review
ENW Wheater, DQ Stoye, SR Cox, JM Wardlaw… - Neuroscience & …, 2020 - Elsevier
MRI has enhanced our capacity to understand variations in brain structure and function
conferred by the genome. We identified 60 studies that report associations between DNA …
conferred by the genome. We identified 60 studies that report associations between DNA …
[HTML][HTML] BECon: a tool for interpreting DNA methylation findings from blood in the context of brain
Tissue differences are one of the largest contributors to variability in the human DNA
methylome. Despite the tissue-specific nature of DNA methylation, the inaccessibility of …
methylome. Despite the tissue-specific nature of DNA methylation, the inaccessibility of …
[HTML][HTML] Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …
[HTML][HTML] Epigenome-wide association study of attention-deficit/hyperactivity disorder symptoms in adults
Background Previous studies have reported associations between attention-
deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first …
deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first …
[HTML][HTML] Human brain region-specific variably methylated regions are enriched for heritability of distinct neuropsychiatric traits
LF Rizzardi, PF Hickey, A Idrizi, R Tryggvadóttir… - Genome biology, 2021 - Springer
Background DNA methylation dynamics in the brain are associated with normal
development and neuropsychiatric disease and differ across functionally distinct brain …
development and neuropsychiatric disease and differ across functionally distinct brain …
[HTML][HTML] Cell type-specific epigenetic links to schizophrenia risk in the brain
Background The importance of cell type-specific epigenetic variation of non-coding regions
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …
[HTML][HTML] Role of DNA methylation in mediating genetic risk of psychiatric disorders
A Starnawska, D Demontis - Frontiers in Psychiatry, 2021 - frontiersin.org
Psychiatric disorders are common, complex, and heritable conditions estimated to be the
leading cause of disability worldwide. The last decade of research in genomics of psychiatry …
leading cause of disability worldwide. The last decade of research in genomics of psychiatry …
A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression
Brain cellular heterogeneity may bias cell type specific DNA methylation patterns,
influencing findings in psychiatric epigenetic studies. We performed fluorescence activated …
influencing findings in psychiatric epigenetic studies. We performed fluorescence activated …