DNA methylation provides a major epigenetic code (besides histone modification) of the
lineage-and developmentspecific genes (such as regulators of differentiation in the …

DNA methylation changes are among the most common detectable abnormalities in human
neoplasia. Hypermethylation within the promoters of selected genes appears to be …

DNA methylation abnormalities have recently emerged as one of the most frequent
molecular changes in hematopoietic neoplasms. Since methylation and transcriptional …

The rapid advances in high‐throughput sequencing technologies have made it more evident
that epigenetic modifications orchestrate a plethora of complex biological processes. During …

Inactivation of tumor suppressor genes is an important event contributing to the development
of neoplasia. In addition to the classic genetic mechanisms of deletion or inactivating point …

The study of DNA methylation has been a rapidly expanding field since its dawn in the
1960s. DNA methylation is an epigenetic modification that plays a crucial role in guiding the …

Targeting DNA methylation for cancer therapy has had a rocky history. The first reports on
DNA methylation changes in cancer described global loss of methylation, which has been …

Epigenetic changes play an important role in cancer pathogenesis. Hypermethylation of
DNA generally results in decreased expression of tumor suppressor genes and defective …

The term epigenetics refers to the heritable changes in gene expression that are not
associated with a change in the actual DNA sequence. Epigenetic dysregulation is linked to …

Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially
contributing to pathogenesis of myeloid malignancies. Several of these diseases, such as …