Melatonin is a hormone with complex roles in the pathogenesis of autoimmune disorders.
Over the years, it has become clear that melatonin may exacerbate some autoimmune …

Multiple sclerosis (MS) is a neuroinflammatory disease of the central nervous system in
which the immune system plays a central role. In particular, effector populations such as T …

Multiple sclerosis (MS) is a devastating chronic autoimmune demyelinating disease of the
central nervous system (CNS), thought to affect more than 2.5 million people worldwide …

Autoimmune diseases are a broad spectrum of disorders involved in the imbalance of T-cell
subsets, in which interplay or interaction of Th1, Th17 and Tregs are most important …

Melatonin is a neurohormone mainly produced by the pineal gland following a circadian
rhythm. It is characterized as a pleiotropic factor because it not only regulates the wake …

Melatonin affects a variety of physiological processes including circadian rhythms, cellular
redox status, and immune function. Importantly, melatonin significantly influences T‐cell …

Melatonin is the major product secreted by the pineal gland at night and displays
multifunctional properties, including immunomodulatory functions. In this study, we …

Background Melatonin is an indole hormone secreted primarily by the pineal gland that
showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important …

Experimental autoimmune encephalomyelitis (EAE), the experimental model for multiple
sclerosis (MS), is triggered by myelin-specific Th1 and Th17 cells. The immunomodulatory …

Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …