Background: Spinal nerve-ligated neuropathy and chemotherapy-induced neuropathy
produce a persistent tactile allodynia in mice. Tianeptine is an antidepressant that exhibits …

We validate the analgesic efficacy of tianeptine by different administration routes and timing
in a rat model of neuropathic pain. Neuropathic pain was induced by ligating the L5 and L6 …

The purpose of this study was to validate the effects of tianeptine on serotonergic and
noradrenergic neurotransmission in a rat model of neuropathic pain. Neuropathic pain was …

Although tianeptine, an atypical antidepressant has been reported to have antinociceptive
effects, the mode of action is different from that of tricyclic antidepressants despite structural …

Background: Although paclitaxel is a frontline antineoplastic agent for treatment of solid
tumors, the paclitaxel-evoked pain syndrome is a serious problem for patients. There is …

Objective: Inflammatory and immune mechanisms play important roles in the pathogenesis
of neuropathic pain. Ceftiofur, a third-generation cephalosporin, has anti-inflammatory …

Pentoxifylline, a non-specific cytokine inhibitor, has shown to be beneficial in inflammatory
pain in both experimental and clinical studies. The present study demonstrates for the first …

Background: Chemotherapy-induced neuropathic pain is difficult to treat. Pentoxifylline
inhibits the production of inflammatory cytokines including tumor necrosis factor α (TNF-α) …

Oxaliplatin, a platinum-based chemotherapy drug, causes neuropathic pain, yet effective
pharmacological treatments are lacking. Previously, we showed that tetrandrine (TET), with …

BACKGROUND: Tianeptine is an atypical antidepressant that exhibits structural similarities
to the tricyclic antidepressants but has distinct neurochemical properties. We evaluated the …