Dynamics of DNA‐demethylation in early mouse and rat embryos developed in vivo and in vitro

I Zaitseva, S Zaitsev, N Alenina, M Bader… - Molecular …, 2007 - Wiley Online Library
Virtually all mammalian species including mouse, rat, pig, cow, and human, but not sheep
and rabbit, undergo genome‐wide epigenetic reprogramming by demethylation of the male …

Methylation reprogramming and chromosomal aneuploidy in in vivo fertilized and cloned rabbit preimplantation embryos

W Shi, F Dirim, E Wolf, V Zakhartchenko… - Biology of …, 2004 - academic.oup.com
Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …

Non-conservation of mammalian preimplantation methylation dynamics

N Beaujean, G Hartshorne, J Cavilla, J Taylor… - Current Biology, 2004 - cell.com
In mammals, active demethylation of sperm pronuclear DNA shortly after fertilisation is
thought to be important for reprogramming subsequent embryonic development [1–3]. A …

Active demethylation of paternal genome in mammalian zygotes

H Abdalla, Y Yoshizawa, S Hochi - Journal of Reproduction and …, 2009 - jstage.jst.go.jp
Epigenetic reprogramming in early preimplantation embryos, that refers to erasing and
remodeling epigenetic marks such as DNA methylation, is essential for differentiation and …

Alteration of DNA demethylation dynamics by in vitro culture conditions in rabbit pre-implantation embryos

AR Reis e Silva, C Bruno, R Fleurot, N Daniel… - Epigenetics, 2012 - Taylor & Francis
Alterations to DNA methylation have been attributed to in vitro culture and may affect normal
embryo development. We chose to analyze DNA methylation reprogramming in the rabbit …

DNA methylation in the preimplantation embryo: the differing stories of the mouse and sheep

LE Young, N Beaujean - Animal reproduction science, 2004 - Elsevier
In mammals, active demethylation of cytosine methylation in the sperm genome prior to
forming a functional zygotic nucleus is thought to be a function of the oocyte cytoplasm …

DNA methylation state is preserved in the sperm-derived pronucleus of the pig zygote.

YS Jeong, S Yeo, JS Park, DB Koo… - International …, 2007 - search.ebscohost.com
DNA methylation reprogramming (DMR) during preimplantation development erases
differentiation-associated, unessential epigenetic information accumulated during …

Methylation dynamics in the early mammalian embryo: implications of genome reprogramming defects for development

T Haaf - DNA methylation: development, genetic disease and …, 2006 - Springer
In mouse and most other mammalian species, the paternal and maternal genomes undergo
parent-specific epigenetic reprogramming during preimplantation development. The …

Impaired active demethylation of the paternal genome in pronuclear‐stage rat zygotes produced by in vitro fertilization or intracytoplasmic sperm injection

Y Yoshizawa, M Kato, M Hirabayashi… - Molecular …, 2010 - Wiley Online Library
This study was designed to investigate the effect of in vitro production systems of rat zygotes
such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) on …

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

M Monk, M Boubelik, S Lehnert - Development, 1987 - journals.biologists.com
This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …