[HTML][HTML] Translational approaches to the biology of Autism: false dawn or a new era?
C Ecker, W Spooren, DGM Murphy - Molecular psychiatry, 2013 - nature.com
Discovering novel treatments for Autism Spectrum Disorders (ASD) is a challenge. Its
etiology and pathology remain largely unknown, the condition shows wide clinical diversity …
etiology and pathology remain largely unknown, the condition shows wide clinical diversity …
Genetic architecture in autism spectrum disorder
B Devlin, SW Scherer - Current opinion in genetics & development, 2012 - Elsevier
Autism spectrum disorder (ASD) is characterized by impairments in reciprocal social
interaction and communication, and by restricted and repetitive behaviors. Family studies …
interaction and communication, and by restricted and repetitive behaviors. Family studies …
Genetic epidemiology and insights into interactive genetic and environmental effects in autism spectrum disorders
YS Kim, BL Leventhal - Biological psychiatry, 2015 - Elsevier
Understanding the pathogenesis of neurodevelopmental disorders has proven to be
challenging. Using autism spectrum disorder (ASD) as a paradigmatic neurodevelopmental …
challenging. Using autism spectrum disorder (ASD) as a paradigmatic neurodevelopmental …
[HTML][HTML] Defining precision medicine approaches to autism spectrum disorders: concepts and challenges
The tremendous clinical and etiological variability between individuals with autism spectrum
disorder (ASD) has made precision medicine the most promising treatment approach. It aims …
disorder (ASD) has made precision medicine the most promising treatment approach. It aims …
The emerging picture of autism spectrum disorder: genetics and pathology
JA Chen, O Peñagarikano, TG Belgard… - Annual Review of …, 2015 - annualreviews.org
Autism spectrum disorder (ASD) is defined by impaired social interaction and
communication accompanied by stereotyped behaviors and restricted interests. Although …
communication accompanied by stereotyped behaviors and restricted interests. Although …
The state of research on the genetics of autism spectrum disorder: methodological, clinical and conceptual progress
AB Arnett, S Trinh, RA Bernier - Current opinion in psychology, 2019 - Elsevier
Highlights•Heterogeneity in autism spectrum disorder presents a challenge to clinical care
and research.•Genetic sequencing indicates disruptive gene variants and CNVs account for …
and research.•Genetic sequencing indicates disruptive gene variants and CNVs account for …
[HTML][HTML] Genetic research in autism spectrum disorders
Genetic studies have the potential to identify the biological underpinnings of ASDs and other
neuropsychiatric disorders. The data they generate are already being used to examine …
neuropsychiatric disorders. The data they generate are already being used to examine …
[HTML][HTML] Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism
Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown
etiology. Recent studies employing exome-and genome-wide sequencing have identified …
etiology. Recent studies employing exome-and genome-wide sequencing have identified …
Autism spectrum disorder genetics: diverse genes with diverse clinical outcomes
ME Talkowski, EV Minikel… - Harvard review of …, 2014 - journals.lww.com
The last several years have seen unprecedented advances in deciphering the genetic
etiology of autism spectrum disorders (ASDs). Heritability studies have repeatedly affirmed a …
etiology of autism spectrum disorders (ASDs). Heritability studies have repeatedly affirmed a …