Clinical and translational implications of an emerging developmental substructure for autism
JN Constantino, T Charman… - Annual review of clinical …, 2021 - annualreviews.org
A vast share of the population-attributable risk for autism relates to inherited polygenic risk. A
growing number of studies in the past five years have indicated that inherited susceptibility …
growing number of studies in the past five years have indicated that inherited susceptibility …
The autism sequencing consortium: large-scale, high-throughput sequencing in autism spectrum disorders
Research during the past decade has seen significant progress in the understanding of the
genetic architecture of autism spectrum disorders (ASDs), with gene discovery accelerating …
genetic architecture of autism spectrum disorders (ASDs), with gene discovery accelerating …
Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
Genetic causes of developmental disorders
JAS Vorstman, RA Ophoff - Current opinion in neurology, 2013 - journals.lww.com
Similar to what is the case for intellectual disability, recent genetic studies indicate a large
degree of genetic heterogeneity for autism and ADHD. Many of the disease risk variants …
degree of genetic heterogeneity for autism and ADHD. Many of the disease risk variants …
Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci
Analysis of de novo CNVs (dnCNVs) from the full Simons Simplex Collection (SSC)(N=
2,591 families) replicates prior findings of strong association with autism spectrum disorders …
2,591 families) replicates prior findings of strong association with autism spectrum disorders …
An overview of autism spectrum disorder, heterogeneity and treatment options
Since the documented observations of Kanner in 1943, there has been great debate about
the diagnoses, the sub-types, and the diagnostic threshold that relates to what is now known …
the diagnoses, the sub-types, and the diagnostic threshold that relates to what is now known …
Genes associated with autism spectrum disorder
X Li, H Zou, WT Brown - Brain research bulletin, 2012 - Elsevier
Autism spectrum disorder (ASD) is a heterogeneous grouping of neurodevelopmental
disorders characterized by impairment in social interaction, verbal communication and …
disorders characterized by impairment in social interaction, verbal communication and …
Identification of common genetic risk variants for autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
Autism spectrum disorder: signaling pathways and prospective therapeutic targets
J Baranova, G Dragunas, MCS Botellho… - Cellular and molecular …, 2021 - Springer
Abstract The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous
group of neurodevelopmental diseases representing a severe burden to affected individuals …
group of neurodevelopmental diseases representing a severe burden to affected individuals …
Autism and environmental genomics
MR Herbert, JP Russo, S Yang, J Roohi, M Blaxill… - Neurotoxicology, 2006 - Elsevier
Autism spectrum disorders (ASD) are defined by behavior and diagnosed by clinical history
and observation but have no biomarkers and are presumably, etiologically and biologically …
and observation but have no biomarkers and are presumably, etiologically and biologically …